| Quality of life is impaired in association with the need for prolonged postoperative therapy by somatostatin analogs in patients with acromegaly. | |
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MedLine Citation:
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PMID: 22250074 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: To assess the influence of long-acting somatostatin analogs (SSTA) after initial pituitary surgery on long-term health-related quality of life (HR-QoL) in relation to disease control in patients with acromegaly.Design: This is a cross-sectional study in two tertiary referral centers in the Netherlands.Patients and methods: 108 patients with acromegaly, in whom transsphenoidal (n=101, 94%) or transcranial (n=7, 6%) surgery was performed. Subsequently, 46 (43%) received additional radiotherapy and 41 (38%) were on postoperative treatment with SSTA because of persistent or recurrent disease at the time of study. All subjects filled in standardized questionnaires measuring HR-QoL. Disease control at the time of study was assessed by local IGF-1 Standard Deviation Scores (SDS).Results: IGF-1 SDS were slightly higher in patients treated with SSTA in comparison to patients without use of SSTA (0.85±1.52 versus 0.25±1.21, P=0.026), but the percentage of patients with insufficient control (IGF-1 SDS > 2) was not different (17% versus 9%, P=0.208). Patients using SSTA reported poorer scores on most subscales of the RAND-36 and the AcroQoL and on all subscales of the MFI-20. A subgroup analysis in patients with similar IGF-1 levels (SSTA+, n=26, IGF-1 SDS 0.44±0.72 versus SSTA -, n=44, IGF-1 SDS 0.41±0.65) revealed worse scores on physical functioning, physical fatigue, reduced activity, vitality and general health perception across all HR-QoL questionnaires in patients treated with SSTA.Conclusion: Quality of life is impaired in association with the need for prolonged postoperative therapy by somatostatin analogs in patients with acromegaly despite similar IGF-1 levels. |
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Authors:
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Mark Roland Postma; Romana T Netea-Maier; Gerrit van den Berg; Jens Homan; Wim J Sluiter; Margreet A Wagenmakers; Alfons C M van den Bergh; Bruce H R Wolffenbuttel; Armm Hermus; Ap van Beek |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-16 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: - ISSN: 1479-683X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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M Postma, Endocrinology, University Medical Center Groningen, Groningen, Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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