Document Detail


Quality of life is impaired in association with the need for prolonged postoperative therapy by somatostatin analogs in patients with acromegaly.
MedLine Citation:
PMID:  22250074     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: To assess the influence of long-acting somatostatin analogs (SSTA) after initial pituitary surgery on long-term health-related quality of life (HR-QoL) in relation to disease control in patients with acromegaly.Design: This is a cross-sectional study in two tertiary referral centers in the Netherlands.Patients and methods: 108 patients with acromegaly, in whom transsphenoidal (n=101, 94%) or transcranial (n=7, 6%) surgery was performed. Subsequently, 46 (43%) received additional radiotherapy and 41 (38%) were on postoperative treatment with SSTA because of persistent or recurrent disease at the time of study. All subjects filled in standardized questionnaires measuring HR-QoL. Disease control at the time of study was assessed by local IGF-1 Standard Deviation Scores (SDS).Results: IGF-1 SDS were slightly higher in patients treated with SSTA in comparison to patients without use of SSTA (0.85±1.52 versus 0.25±1.21, P=0.026), but the percentage of patients with insufficient control (IGF-1 SDS > 2) was not different (17% versus 9%, P=0.208). Patients using SSTA reported poorer scores on most subscales of the RAND-36 and the AcroQoL and on all subscales of the MFI-20. A subgroup analysis in patients with similar IGF-1 levels (SSTA+, n=26, IGF-1 SDS 0.44±0.72 versus SSTA -, n=44, IGF-1 SDS 0.41±0.65) revealed worse scores on physical functioning, physical fatigue, reduced activity, vitality and general health perception across all HR-QoL questionnaires in patients treated with SSTA.Conclusion: Quality of life is impaired in association with the need for prolonged postoperative therapy by somatostatin analogs in patients with acromegaly despite similar IGF-1 levels.
Authors:
Mark Roland Postma; Romana T Netea-Maier; Gerrit van den Berg; Jens Homan; Wim J Sluiter; Margreet A Wagenmakers; Alfons C M van den Bergh; Bruce H R Wolffenbuttel; Armm Hermus; Ap van Beek
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-16
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  -     ISSN:  1479-683X     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
M Postma, Endocrinology, University Medical Center Groningen, Groningen, Netherlands.
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