Document Detail

Quality of life and functional capacity can be improved in patients with Eisenmenger syndrome with oral sildenafil therapy.
MedLine Citation:
PMID:  20304507     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Patients with Eisenmenger syndrome (ES) have a decreased exercise capacity and poor quality of life (QoL). While patients may survive to middle adulthood, the burden of disease is disabling. Sildenafil seems to improve exercise tolerance and hemodynamics, but there is no data to date on its impact on QoL.
METHODS: Eisenmenger patients in New York Heart Association (NYHA) class III were recruited in a prospective study of efficacy and safety of oral sildenafil. The QoL endpoint was assessed using a disease-specific questionnaire (CAMPHOR). Exercise capacity was assessed by means of six minute walk test (6MWT). All patients underwent comprehensive assessment at baseline and after 3months of treatment.
RESULTS: Twelve patients (mean age was 34.3±10.2, 83% female) with various cardiac anatomies were recruited. No major adverse events during the follow-up or significant drop in resting oxygen saturation were recorded. After 3months of oral sildenafil therapy, all patients improved to NYHA II with a concomitant improvement in 6MWT distance (347.3±80.7 to 392.5±82.0m, p=0.002). All components of the CAMPHOR score, relating to symptoms, activity and QoL, improved significantly resulting in substantial improvement in the total CAMPHOR score (27.6±10.5 to 15.8±10.4, p=0.002).
CONCLUSIONS: Three months of sildenafil therapy in adults with ES was well tolerated and associated with significant improvement in the QoL CAMPHOR questionnaire and in NYHA class and exercise capacity. Larger studies are warranted to assess long term efficacy of oral sildenafil and potential impact on survival.
Edgar L W Tay; Maria Papaphylactou; Gerhard Paul Diller; Rafael Alonso-Gonzalez; Ryo Inuzuka; Georgios Giannakoulas; Carl Harries; Stephen John Wort; Lorna Swan; Konstantinos Dimopoulos; Michael A Gatzoulis
Related Documents :
3894867 - Psychogenic factors and exercise metabolism: a review.
3581587 - Epidemiology. the incidence and management of joint contracture in india.
20468607 - Physical therapy for rheumatic disease.
25330347 - Differential effects of exercise on brain opioid receptor binding and activation in rats.
1029457 - Exercise training as a therapeutic modality.
11255807 - Metachromasia of the endocervical epithelium for delineating the internal os.
Publication Detail:
Type:  Journal Article     Date:  2010-03-20
Journal Detail:
Title:  International journal of cardiology     Volume:  149     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  372-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Haloperidol induces higher Homer1a expression than risperidone, olanzapine and sulpiride in striatal...
Next Document:  A stochastic risk-analysis model for the spread of bovine viral diarrhea virus after introduction to...