Document Detail

Quality of life, epilepsy advances, and the evolving role of anticonvulsants in women with epilepsy.
MedLine Citation:
PMID:  11001359     Owner:  NLM     Status:  MEDLINE    
In the United States, approximately 1.1 million women of childbearing age have epilepsy. Even though antiepileptic drugs (AEDs) control the seizures of about 80% of patients with epilepsy, the management of women with epilepsy (WWE) presents physicians with unique problems, ranging from the cosmetic consequences of some AEDs (e.g., changes in weight) to the seizures of catamenial epilepsy (apparently related to a relative lack of progesterone during the luteal phase of the menstrual cycle). In addition, the effectiveness of hormonal contraceptives can be reduced by enzyme-inducing AEDs. The pregnancies of WWE present a greater risk for complications: one-quarter to one-third of WWE experience an increase in seizure frequency. In addition, difficulties during labor and adverse outcomes (e.g., fetal mortality and malformations, neonatal hemorrhage, low birth weight, and developmental delay) are more likely. The practitioner must choose a course that both prevents seizures and minimizes fetal exposure to AEDs.
M S Yerby
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurology     Volume:  55     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  2000  
Date Detail:
Created Date:  2000-10-16     Completed Date:  2000-10-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S21-31; discussion S54-8     Citation Subset:  AIM; IM    
North Pacific Epilepsy Research and the Department of Neurology, Public Health and Preventive Medicine, Oregon Health Sciences University, Portland 97210, USA.
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MeSH Terms
Anticonvulsants / therapeutic use*
Epilepsy / drug therapy*,  physiopathology
Pregnancy / drug effects*,  physiology
Quality of Life*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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