| Quality of life and depression assessment in nevoid basal cell carcinoma syndrome. | |
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MedLine Citation:
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PMID: 21342158 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background Nevoid basal cell carcinoma syndrome (NBCCS) is a rare genetic disease which causes a variety of dermatological lesions, especially basal cell carcinomas (BCCs), often on the face, neck, and head. Methods Persons attending a national NBCCS support group meeting were asked to participate in survey-based assessments of quality of life and depressive symptoms. Inclusion criteria required a self-reported NBCCS diagnosis, voluntary agreement to participate, and age over 18 years. Exclusion criteria included cognitive impairment. Skin-related quality of life was assessed with Skindex-29, completed by 32 participants. Depressive symptomatology was determined with the Center for Epidemiological Studies Depression Scale (CES-D), completed by 18 participants. Sociodemographic, medical, and social variables were also analyzed. Results Median Skindex-29 scores for the emotions, symptoms, and functioning scales were 42.50, 32.14, and 28.13, respectively (means: 41.17, 37.05, and 29.30, respectively). These scores were slightly higher than those observed in patients with neurofibromatosis type 1, a similar genetic disease with skin symptoms. The CES-D scores (median = 15.50, mean = 17.50) suggested that 50% of participants had significant depressive symptomatology. Variables showing moderate associations with the scores included diet, number of affected family members, and treatment type. Interestingly, the number of BCCs had no effect. Conclusions Nevoid basal cell carcinoma syndrome impacts the quality of life of its subjects in a similar manner to other genodermatoses. Depressive symptoms are particularly prevalent. Several demographic, medical, and social characteristics affect these outcomes. Thus, the psychological impact of this disorder should be evaluated in the course of considering the care of persons with NBCCS. |
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Authors:
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Maulik Shah; Melissa Mavers; Alanna Bree; Scott Fosko; Nathan H Lents |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of dermatology Volume: 50 ISSN: 1365-4632 ISO Abbreviation: Int. J. Dermatol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243704 Medline TA: Int J Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 268-76 Citation Subset: IM |
Copyright Information:
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© 2011 The International Society of Dermatology. |
Affiliation:
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Saint Louis University Cancer Center, St Louis, MO, USA Department of Otolaryngology Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, MO, USA Department of Dermatology, Baylor College of Medicine, Houston, TX, USA Department of Dermatology, Saint Louis University School of Medicine, St Louis, MO, USA Department of Sciences, John Jay College, City University of New York, New York, NY, USA. |
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