| Quality of life beyond 6 months after diagnosis in older adults with acute myeloid leukemia. | |
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MedLine Citation:
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PMID: 18778950 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although intensive chemotherapy may improve survival in older people with acute myeloid leukemia (AML) without adverse cytogenetics, its impact on quality of life (QOL) is mixed and most patients complain of fatigue up to 6 months after diagnosis. Little information is available on longer-term QOL outcomes. We prospectively followed 20 patients age 60 or older with AML who provided QOL data more than 6 months after diagnosis. Over the first 6 months, there were clinically important improvements in global health, role function, social function, and emotional function. Physical function and cognitive function were stable over time. Over the next 6 months, social function and fatigue improved, and other domains remained stable. Achievement of complete remission appeared to be associated with improvements in global health, physical function, and role function without negatively affecting other health domains. This information may aid discussions with patients about treatment. |
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Authors:
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Shabbir M H Alibhai; Marc Leach; Vikas Gupta; George A Tomlinson; Joseph M Brandwein; Fernando Suarez Saiz; Mark D Minden |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-07 |
Journal Detail:
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Title: Critical reviews in oncology/hematology Volume: 69 ISSN: 1879-0461 ISO Abbreviation: Crit. Rev. Oncol. Hematol. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-12 Completed Date: 2009-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8916049 Medline TA: Crit Rev Oncol Hematol Country: Ireland |
Other Details:
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Languages: eng Pagination: 168-74 Citation Subset: IM |
Affiliation:
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Division of General Internal Medicine & Clinical Epidemiology, University Health Network, Toronto, Canada. shabbir.alibhai@uhn.on.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Cognition Emotions Fatigue / physiopathology Female Follow-Up Studies Humans Leukemia, Myeloid, Acute / diagnosis, drug therapy*, physiopathology*, psychology Male Middle Aged Prospective Studies Quality of Life Remission Induction |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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