Document Detail

Quality of life before and during antihypertensive treatment: a comparative study of celiprolol and atenolol.
MedLine Citation:
PMID:  8832309     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The well-being of hypertensive patients may be adversely affected by the disease itself, its complications, and other concomitant processes such as anxiety, sedation, and side effects of the prescribed drugs. Some recently developed antihypertensive agents have been suggested to be devoid of these deleterious effects on well-being expressed as quality of life. OBJECT: We compared the effect on quality of life of a standard cardioselective beta-blocker atenolol to the effect of celiprolol as a representative of a new class of selective beta-blockers with vasodilatory properties. One-hundred-thirty-two patients with mild to moderate hypertension were eligible to enter a 28-week double-blind parallel-group study, consisting of a 4-week run-in period on placebo and a 24-week period on dosage-adjusted treatment with either atenolol or celiprolol. RESULTS: Both systolic and diastolic blood pressure were assessed, as was quality of life perception by a selected test battery including the Quality of Life Questionnaire of Bulpitt and Fletcher [1990]. During celiprolol treatment, supine blood pressure fell from 167/101 (range 120-200/95-116) to 150/92 mm Hg (p < 0.0001). This antihypertensive effect was at least as good with celiprolol as with atenolol. Quality of life perception was comparable for the 2 drugs, although some adverse effects were more frequent during atenolol than during celiprolol, particularly after prolonged treatment. Also patient compliance was better for celiprolol than for atenolol. CONCLUSIONS: Our results show that the selective beta-blocker with vasodilatory property celiprolol is at least as effective as atenolol and that it has additional advantage in terms of enhancement of some quality of life variables.
T J Cleophas; N van der Mey; J van der Meulen; M G Niemeyer
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of clinical pharmacology and therapeutics     Volume:  34     ISSN:  0946-1965     ISO Abbreviation:  Int J Clin Pharmacol Ther     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-26     Completed Date:  1996-12-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423309     Medline TA:  Int J Clin Pharmacol Ther     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  312-7     Citation Subset:  IM    
Department of Medicine, Merwede Hospital Dordrecht, Netherlands.
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MeSH Terms
Aged, 80 and over
Antihypertensive Agents / adverse effects*,  therapeutic use*
Atenolol / adverse effects*,  therapeutic use*
Celiprolol / adverse effects*,  therapeutic use*
Double-Blind Method
Hypertension / drug therapy*,  psychology*
Middle Aged
Patient Compliance
Quality of Life*
Reg. No./Substance:
0/Antihypertensive Agents; 29122-68-7/Atenolol; 56980-93-9/Celiprolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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