Document Detail

Quality-of-life assessment after hyperfractionated radiation therapy and 5-fluorouracil, cisplatin, and paclitaxel (Taxol) in inoperable and/or unresectable head and neck squamous cell carcinoma.
MedLine Citation:
PMID:  16062077     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine quality of life (QOL) after hyperfractionated radiation and chemotherapy. MATERIALS AND METHODS: Functional Assessment of Cancer Therapy (FACT) and the Functional Assessment of Cancer Therapy-Head and Neck (FACT H-N) questionnaires were administered to protocol patients at baseline study entry, during and at the completion of therapy, and during subsequent follow-up. RESULTS: Twenty-four patients completed baseline QOL questionnaires. Six subsequent assessments were given to patients who were available for follow-up. Social/family well-being and relationship with doctor subscores were not significantly different from baseline. Emotional well-being was not different from baseline initially, but actually showed a significant increase 6 months after completion of radiation, seen on assessments 5 and 6 (P < 0.01). Physical and functional well-being subscores, total FACT-G score, head and neck subscores, and total FACT H-N score all showed initial decreases during, at the completion of radiation, or, in some subscores, up to 3 months postradiation. However, all these scores recovered to baseline levels. These scores subsequently showed a significant increase after 6 months to 1 year in all but the physical well-being and head and neck subscores, which remained at baseline. CONCLUSION: QOL scores returned to baseline levels or increased at 6 to 12 months postradiation in long-term survivors who completed QOL questionnaires.
May Abdel-Wahab; Andre Abitbol; Alan Lewin; Michael Troner; Kara Hamilton; Arnold Markoe
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Publication Detail:
Type:  Clinical Trial; Journal Article; Validation Studies    
Journal Detail:
Title:  American journal of clinical oncology     Volume:  28     ISSN:  1537-453X     ISO Abbreviation:  Am. J. Clin. Oncol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-02     Completed Date:  2005-11-21     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  8207754     Medline TA:  Am J Clin Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  359-66     Citation Subset:  IM    
Department of Radiation Oncology, University of Miami, Miami, Florida 33136, USA.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / adverse effects,  therapeutic use*
Carcinoma, Squamous Cell / mortality,  pathology,  therapy*
Cisplatin / administration & dosage
Disease-Free Survival
Dose Fractionation
Drug Eruptions / etiology
Esophageal Stenosis / etiology
Fluorouracil / administration & dosage
Follow-Up Studies
Gastrostomy / adverse effects
Head and Neck Neoplasms / mortality,  pathology,  therapy*
Hematologic Diseases / chemically induced
Middle Aged
Neoplasm Staging
Paclitaxel / administration & dosage
Quality of Life*
Radiotherapy, Adjuvant*
Survival Rate
Reg. No./Substance:
15663-27-1/Cisplatin; 33069-62-4/Paclitaxel; 51-21-8/Fluorouracil

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