| Quality of life after randomization to laparoscopic versus open living donor nephrectomy: long-term follow-up. | |
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MedLine Citation:
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PMID: 17627239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this randomized study was to compare patient-reported outcome after laparoscopic versus open donor nephrectomy during 1 year follow-up. The evidence base has so far not allowed for a decision as to which method is superior as seen from a long-term quality of life-perspective. METHODS: The donors were randomized to laparoscopic (n=63) or open (n=59) nephrectomy, with follow-up at 1, 6, and 12 months. Primary outcomes were health status (SF-36) and overall quality of life (QOLS-N). Secondary outcomes were donor perception of the surgical scar, the donation's impact on personal finances, and whether the donor would make the same decision to donate again. RESULTS: There was a significant difference in favor of laparoscopic surgery regarding the SF-36 subscale bodily pain at 1 month postoperatively (P<0.05). Analysis based on intention to treat revealed no long-term differences between groups in SF-36 scores. When subtracting the reoperated/converted donors of the laparoscopic group, significant differences in favor of laparoscopy were revealed in the subscales bodily pain at 6 months (P<0.05) and social functioning at 12 months (P<0.05). No significant differences were found in QOLS-N scores between groups. CONCLUSIONS: Laparoscopic donor nephrectomy is an attractive alternative to open donor nephrectomy because of less postoperative pain. However, long-term comparison only revealed significant differences in favor of laparoscopy when adjusting for reoperations/conversions. Both groups reached baseline scores in most SF-36 subscales at 12 months and this may explain why possible minor benefits are hard to prove. |
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Authors:
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Marit Helen Andersen; Lars Mathisen; Marijke Veenstra; Ole Oyen; Bjørn Edwin; Randi Digernes; Gunnvald Kvarstein; Tor Inge Tønnessen; Astrid Klopstad Wahl; Berit Rokne Hanestad; Erik Fosse |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transplantation Volume: 84 ISSN: 0041-1337 ISO Abbreviation: Transplantation Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-13 Completed Date: 2007-08-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: United States |
Other Details:
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Languages: eng Pagination: 64-9 Citation Subset: IM |
Affiliation:
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Department of Surgery, Rikshospitalet-Radiumhospitalet Medical Centre, Oslo, Norway. marit.andersen@rikshospitalet.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Health Status Humans Interpersonal Relations Laparoscopy* Living Donors* Longitudinal Studies Male Middle Aged Nephrectomy / methods* Pain, Postoperative / physiopathology Postoperative Period Quality of Life* Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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