| Quality evaluation of magnesium oxide tablets using acid neutralization test and dissolution test | |
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MedLine Citation:
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PMID: 18057798 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For the purpose of quality evaluation of commercially available magnesium oxide (MgO) tablets, we studied their acid neutralization and dissolution behaviors. The dissolution test was carried out by the paddle method in 1st fluid (pH 1.2). The dissolution amount of MgO from tablets was determined by chelatometric titration. The medium pH was periodically measured. The neutralization reaction in 750 ml of 1st fluid was markedly different between two kinds of commercial tablets. The pH of medium including Magmit tablet reached 8.9 and the dissolution rate of MgO was 81.1% after 20 min. Contrariwise, the final pH of medium including Maglax tablet was 2.5 and the dissolution rate of MgO was 77.1% after 60 min. These results indicate that the dissolution rate of MgO from tablets should be >81.1% to obtain significant acid neutralization action. |
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Authors:
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Chiaki Inoue; Toshiaki Kogure; Aya Kamata; Mika Ishihara; Reiko Muraoka; Akitoshi Tatsumi; Kuniyoshi Tanaka; Harunori Takeshita; Tsuneo Hamaguchi; Noriko Tagawa; Yoshiharu Kobayashi; Muneo Kadobayashi |
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Publication Detail:
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Type: English Abstract; Journal Article |
Journal Detail:
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Title: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Volume: 127 ISSN: 0031-6903 ISO Abbreviation: Yakugaku Zasshi Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-02-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413613 Medline TA: Yakugaku Zasshi Country: Japan |
Other Details:
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Languages: jpn Pagination: 2085-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacy, The Hospital of Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya City 6633-8501, Japan. ykinochi@hyo-med.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chemistry, Pharmaceutical Hydrogen-Ion Concentration Magnesium Oxide* / analysis Quality Control* Solubility Tablets Titrimetry |
| Chemical | |
Reg. No./Substance:
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0/Tablets; 1309-48-4/Magnesium Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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