Document Detail

Quality of care for acute coronary syndrome patients with known atherosclerotic disease: results from the Get With the Guidelines Program.
MedLine Citation:
PMID:  19652090     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Patients with prior atherosclerosis in 1 or more vascular territories (coronary, cerebrovascular, or peripheral arterial) who present with acute coronary syndromes have high cardiovascular risk and may benefit significantly from evidence-based therapies, yet whether these are used consistently is unknown. METHODS AND RESULTS: The Get With the Guidelines-Coronary Artery Disease database was queried to determine whether compliance with quality-of-care treatments for acute coronary syndrome patients was associated with the extent of prior vascular disease. A total of 143 999 patients enrolled at 438 sites between January 2000 and January 2008 were classified according to the absence (n=98 136; 68%) or presence of known preexistent atherosclerosis (before admission) in 1, 2, or 3 vascular territories (n=37 633 [26%], n=7369 [5%], and n=861 [0.6%], respectively). Overall in-hospital mortality was 5.3%, and mean length of stay was 5.6+/-6.7 days. Compared with patients without prior vascular disease, patients with prior vascular disease were older and had more comorbidities. They were less likely to undergo coronary revascularization and had longer duration of hospital stay and higher in-hospital mortality. After adjustment for clinical and hospital characteristics, compared with patients without prior vascular disease, patients with prior vascular disease had higher mortality and were less likely to receive 3 particular treatments (lipid-lowering therapy, smoking cessation counseling, and angiotensin-converting enzyme inhibitor for left ventricular dysfunction). CONCLUSIONS: Compared with acute coronary syndrome patients without prior vascular disease, those with prior atherosclerosis had higher in-hospital mortality yet were paradoxically less likely to receive specific evidence-based acute coronary syndrome treatments, which can form the basis for targeted intervention.
Emmanouil S Brilakis; Adrian F Hernandez; David Dai; Eric D Peterson; Subhash Banerjee; Gregg C Fonarow; Christopher P Cannon; Deepak L Bhatt
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-03
Journal Detail:
Title:  Circulation     Volume:  120     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-18     Completed Date:  2009-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  560-7     Citation Subset:  AIM; IM    
VA North Texas Healthcare System and University of Texas Southwestern Medical Center, Dallas, USA.
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MeSH Terms
Acute Coronary Syndrome / etiology*,  mortality,  therapy*
Aged, 80 and over
American Heart Association
Angioplasty, Transluminal, Percutaneous Coronary
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Antilipemic Agents / therapeutic use
Coronary Artery Disease / complications*,  mortality,  therapy*
Guideline Adherence*
Hospital Mortality
Length of Stay
Middle Aged
Practice Guidelines as Topic*
Quality Assurance, Health Care*
Retrospective Studies
Smoking Cessation
United States
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antilipemic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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