| Quality assurance in the EORTC 22033-26033/CE5 phase III randomized trial for low grade glioma: The digital individual case review. | |
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MedLine Citation:
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PMID: 22560713 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: The phase III EORTC 22033-26033/NCIC CE5 intergroup trial compares 50.4Gy radiotherapy with up-front temozolomide in previously untreated low-grade glioma. We describe the digital EORTC individual case review (ICR) performed to evaluate protocol radiotherapy (RT) compliance. METHODS: Fifty-eight institutions were asked to submit 1-2 randomly selected cases. Digital ICR datasets were uploaded to the EORTC server and accessed by three central reviewers. Twenty-seven parameters were analysed including volume delineation, treatment planning, organ at risk (OAR) dosimetry and verification. Consensus reviews were collated and summary statistics calculated. RESULTS: Fifty-seven of seventy-two requested datasets from forty-eight institutions were technically usable. 31/57 received a major deviation for at least one section. Relocation accuracy was according to protocol in 45. Just over 30% had acceptable target volumes. OAR contours were missing in an average of 25% of cases. Up to one-third of those present were incorrectly drawn while dosimetry was largely protocol compliant. Beam energy was acceptable in 97% and 48 patients had per protocol beam arrangements. CONCLUSIONS: Digital RT plan submission and review within the EORTC 22033-26033 ICR provide a solid foundation for future quality assurance procedures. Strict evaluation resulted in overall grades of minor and major deviation for 37% and 32%, respectively. |
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Authors:
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Alysa Fairchild; Damien C Weber; Raquel Bar-Deroma; Akos Gulyban; Paul A Fenton; Roger Stupp; Brigitta G Baumert |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-2 |
Journal Detail:
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Title: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Volume: - ISSN: 1879-0887 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8407192 Medline TA: Radiother Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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EORTC Headquarters, Brussels, Belgium; Radiation Oncology, Cross Cancer Institute, Edmonton, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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