| Quality of sexual life in hyperandrogenic women treated with an oral contraceptive containing chlormadinone acetate. | |
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MedLine Citation:
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PMID: 19832931 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Hyperandrogenism produces change in quality of life of women. AIM: To prespectively determine the changes of the sexual behaviour of hyperandrogenic women using an oral contraceptive containing 30 microg ethinylestradiol and 2 mg chlormadinone acetate (EE/CMA). METHODS: Seventy-two volunteer women (age range, 18-32 years), with moderate to severe hirsutim and acne were treated with EE/CMA for 9 cycles. MAIN OUTCOMES MEASURE(S): To assess hirsutism, the Ferriman-Gallwey (F-G) scoring system was used. Serum FSH, LH, estradiol, total and free testosterone, DHEAS, androstenedione, and SHBG levels were measured at baseline and at the 9th cycle of pill intake. The Short Personal Experience Questionnaire (SPEQ), the Short Form-36 (SF-36), and a visual analog scales questionnaires were used to assess the QoL, at baseline and after 3, 6 and 9 cycles of pill use. RESULT(S): A reduction of 65% and 81% in the total mean F-G score was observed after the 6th cycle and the 9th cycle, respectively. The serum Androstenedione, and total and free testosterone levels decreased, and SHBG levels increased after the 9th cycle (p < 0.05). The SF-36 score was higher after 6 (p < 0.05) 9 cycles (p < 0.001) with respect to baseline. Frequency of sexual intercourse and of orgasm by intercourse increased, and the frequency of masturbation decreased during the 6th (p < 0.05) and the 9th cycle (p < 0.001). CONCLUSION(S): The EE/CMA pill has anti-androgenic properties reducing the anti-aesthetic effect of hyperandrogenism and improving female sexual and social self-esteem. |
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Authors:
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Salvatore Caruso; Salvatore Rugolo; Carmela Agnello; Mattea Romano; Antonio Cianci |
Publication Detail:
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Type: Journal Article Date: 2009-10-14 |
Journal Detail:
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Title: The journal of sexual medicine Volume: 6 ISSN: 1743-6109 ISO Abbreviation: J Sex Med Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-01-22 Completed Date: 2010-04-15 Revised Date: 2011-08-25 |
Medline Journal Info:
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Nlm Unique ID: 101230693 Medline TA: J Sex Med Country: United States |
Other Details:
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Languages: eng Pagination: 3376-84 Citation Subset: IM |
Affiliation:
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Research Group for Sexology, Department of Microbiological Science and Gynaecological Science, University of Catania, Catania, Italy. scaruso@unict.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
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diagnosis,
epidemiology Adolescent Androgen Antagonists / therapeutic use Chlormadinone Acetate / therapeutic use* Coitus Contraceptives, Oral, Synthetic / therapeutic use* Female Hirsutism / diagnosis, epidemiology Humans Hyperandrogenism / drug therapy*, epidemiology* Polycystic Ovary Syndrome / epidemiology Prospective Studies Quality of Life / psychology* Questionnaires Self Concept Severity of Illness Index Sexual Behavior / psychology* Time Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Androgen Antagonists; 0/Contraceptives, Oral, Synthetic; 302-22-7/Chlormadinone Acetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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