| Quality and quantity of diffuse and focal white matter disease and cognitive disability of patients with multiple sclerosis. | |
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MedLine Citation:
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PMID: 20626570 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Using high-field magnetic resonance imaging (MRI), we investigated the relationships between white matter (WM) lesion volume (LV), normal-appearing WM (NAWM) normalized volume, WM-lesion and NAWM magnetization transfer ratios (MTRs), brain parenchyma fraction (BPF), and cognitive impairment (CI) in multiple sclerosis (MS). METHODS: Twenty-four patients and 24 healthy volunteers (age, sex, and years of education-matched) underwent a 3.0 Tesla (3T) scan and evaluation of depression, fatigue, and CI using the Minimal Assessment of Cognitive Function in MS (MACFIMS) battery. RESULTS: In this clinically relatively well-preserved cohort of patients (median score on the Expanded Disability Status Scale = 1.5), CI was detected on Symbol Digit Modalities Test (SDMT), California Verbal Learning Test-II (CVLT-II), and Controlled Oral Word Association Test. MT data were available in 19 pairs on whom correlation analyses were performed. Associations were seen between SDMT and normalized NAWM volume (P= .034, r= .502), CVLT-II long delay and normalized NAWM volume (P= .012, r= .563), WM-LV (P= .024, r= .514), and BPF (P= .002, r= .666). CONCLUSIONS: The use of 3T MRI in a sample of clinically stable MS patients shows the importance of WM disease in hampering processing speed and word retrieval. |
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Authors:
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Giuseppe Bomboi; Vasiliki N Ikonomidou; Stefano Pellegrini; Susan K Stern; Antonio Gallo; Sungyoung Auh; Iordanis E Evangelou; Jhalak Agarwal; Clelia Pellicano; Joan M Ohayon; Fredric K Cantor; Mary Ehrmantraut; Henry F McFarland; Robert L Kane; Francesca Bagnato |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 21 ISSN: 1552-6569 ISO Abbreviation: J Neuroimaging Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: United States |
Other Details:
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Languages: eng Pagination: e57-63 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 by the American Society of Neuroimaging. |
Affiliation:
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From the Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD (GB, VNI, SP, SKS, AG, IEE, JA, CP, JMO, FKC, ME, HFM, FB); Office of the Clinical Director, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD (SA); VA Maryland Healthcare System (RLK). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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