Document Detail

Quality of Pediatric Second-degree Burn Wound Scars Following the Application of Basic Fibroblast Growth Factor: Results of a Randomized, Controlled Pilot Study .
MedLine Citation:
PMID:  22879314     Owner:  NLM     Status:  In-Data-Review    
Pediatric burn wounds present unique challenges. Second-degree burns may increase in size and depth, raising con- cerns about healing and long-term scarring. Results of a clinical study in adults with second-degree burn wounds sug- gest that application of basic fibroblast growth factor (bFGF) may reduce time to second-intention healing and result in a more cosmetically acceptable scar. To evaluate the effect of this treatment on pediatric patients with deep second- degree burn wounds, 20 pediatric patients ranging in age from 8 months to 3 years (average 1 year, 3 months [± 6 months]) with a total of 30 burn wounds from various causes were allocated either the growth factor (treatment, n = 15) or an impregnated gauze treatment (control, n = 15). Wounds still exudative (not healed) after 21 days were covered with a split-thickness skin graft. All wounds were clinically assessed until healed and after 1 year. A moisture meter was used to assess scars of wounds healing by secondary intention. A color meter was used to evaluate grafted wounds. Five wounds in each group required grafting. Skin/scar color match was significantly closer to 100% in the treatment than in the control group (P <0.01). Wounds not requiring grafting were no longer exudative after 13.8 (± 2.4) and 17.5 (± 3.1) days in the treatment (n = 10) and control group (n = 10), respectively (P <0.01). After 1 year, scar pigmentation, pliability, height, and vascularity were also significantly different (P <0.01) between the groups. Hypertrophic scars developed in 0 of 10 wounds in the treatment and in three of 10 wounds in the control group, and effective contact coefficient, tran- sepidermal water loss, water content, and scar thickness were significantly greater in control group (P <0.01). Both the short- and long-term results of this treatment in pediatric burn patients are encouraging and warrant further research.
Kenji Hayashida; Sadanori Akita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ostomy/wound management     Volume:  58     ISSN:  1943-2720     ISO Abbreviation:  Ostomy Wound Manage     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912029     Medline TA:  Ostomy Wound Manage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32-6     Citation Subset:  N    
Department of Plastic and Reconstructive Surgery, National Nagasaki Medical Center, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan; email:
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