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Quality of Life in Patients After Pancreaticoduodenectomy for Chronic Pancreatitis.
MedLine Citation:
PMID:  21512849     Owner:  NLM     Status:  Publisher    
PURPOSE: Pancreaticoduodenectomy (PD) is the most frequently performed resectional procedure in chronic pancreatitis. Only a few studies have evaluated quality of life (QOL) after PD for chronic pancreatitis. This retrospective study examined long-term quality of life and relief of symptoms in a homogenous consecutive cohort of 67 patients undergoing PD for chronic pancreatitis. METHODS: A standard QOL questionnaire was sent to 168 patients after PD who had undergone PD for chronic pancreatitis at the University Hospital Dresden between 1994 and 2008. QOL and long-term sequelae were evaluated by the EORTC quality of life questionnaire supplemented with complementary questions. Results were compared to general population data based on large random samples. RESULTS: Median follow-up was 69.1 months. Complete response was obtained from 67 (48.5%) patients. Long-term survival of our patients was lower than expected rates based on the Federal Republic of Germany life table analysis (p < 0.001). There was an improved pain control and an increase in weight gain. Overall, QOL scores were slightly inferior to those of the control group. A common problem after PD was onset of diabetes mellitus; however, exocrine function of the pancreas was stable. CONCLUSIONS: This is the largest single-institution experience assessing QOL after PD for chronic pancreatitis. Most patients have QOL scores comparable to those of the control patients and can function independently in daily activities.
Felix Rückert; Marius Distler; Sven Hoffmann; Doreen Hoffmann; Christian Pilarsky; Frank Dobrowolski; Hans-Detlev Saeger; Robert Grützmann
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-22
Journal Detail:
Title:  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract     Volume:  -     ISSN:  1873-4626     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706084     Medline TA:  J Gastrointest Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany,
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