Document Detail

Quality of Life assessment through the EORTC questionnaires of locally advanced rectal cancer patients treated with preoperative chemo-radiotherapy.
MedLine Citation:
PMID:  16790395     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the quality of life in a group of rectal cancer patients during the treatment period. MATERIAL AND METHODS: A sample of 83 rectal cancer patients in Dukes' stages B2 or C who started a chemoradiotherapy treatment followed by surgery, have filled in the EORTC core questionnaire QLQC30 and the colorectal module QLQ-CR38, in three moments during the treatment and follow-up periods: at the beginning of the treatment, at the end of the chemoradiotherapy, and after surgery. Clinical and demographic data have also been recorded. Quality of Life scores and changes in them among the three assessments have been calculated. RESULTS: Quality of life scores of patients who have followed the treatment has been good in most dimensions, and has shown similar to the clinical data. Soft and moderate alterations have appeared in the areas of disease symptoms, treatment toxicity, fatigue, emotional and sexual functioning, and also in functional areas after surgery. Quality of life has been stable or has had small changes in most dimensions. A worsening in toxicity areas has appeared after the neoadyuvant treatment. After surgery there has been a worsening in functional areas, fatigue and appetite loss, and an improvement in diarrhoea. CONCLUSIONS: Quality of life scores and clinical data indicate that the situation of the patients who have received the treatments has been good. Patients under treatment stood it adequately.
Juan Ignacio Arraras Urdaniz; Fernando Arias de la Vega; Ruth Vera García; Ana Manterola Burgaleta; Maite Martínez Aguillo; Elena Villafranca Iturre; Esteban Salgado Pascual
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico     Volume:  8     ISSN:  1699-048X     ISO Abbreviation:  -     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-22     Completed Date:  2006-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101247119     Medline TA:  Clin Transl Oncol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  423-9     Citation Subset:  IM    
Servicios de Oncología Radioterápica y Oncología Médica, Hospital de Navarra, Pamplona, Navarra, Spain.
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MeSH Terms
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols / adverse effects,  therapeutic use
Body Image
Fluorouracil / administration & dosage,  adverse effects
Follow-Up Studies
Gastrointestinal Diseases / chemically induced
Middle Aged
Neoadjuvant Therapy*
Neoplasm Staging
Preoperative Care
Quality of Life*
Radiotherapy / adverse effects
Rectal Neoplasms / drug therapy,  pathology,  psychology*,  radiotherapy,  surgery
Sexual Behavior
Tegafur / administration & dosage,  adverse effects
Urination Disorders / etiology
Reg. No./Substance:
17902-23-7/Tegafur; 51-21-8/Fluorouracil

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