Document Detail

Quality of Life Assessment in the Randomized PROTECT AF Trial of Patients at Risk for Stroke with Non-valvular Atrial Fibrillation.
MedLine Citation:
PMID:  23500276     Owner:  NLM     Status:  Publisher    
BACKGROUND: The PROTECT AF trial demonstrated that in patients with non-valvular AF and CHADS2 ≥ 1, a LAA closure device is non-inferior to long-term warfarin for stroke prevention. Given this equivalency, quality of life (QOL) indicators are an important metric for evaluating these two different strategies. METHODS: QOL using the SF-12-V2 measurement tool was obtained at baseline and 12 months in a subset of 547 patients in the PROTECT AF Trial (361 device and 186 warfarin patients). The analysis cohort consisted of those for whom either paired quality of life data was available after 12 months follow-up or in patients that died. RESULTS: With the device, the total physical score improved in 34.9% and was unchanged in 29.9% vs. warfarin in whom 24.7% were improved and 31.7% were unchanged (p=0.01). Mental health improvement occurred in 33.0% of the device group vs. 22.6% in the warfarin group (p=0.06). There was a significant improvement in QOL in patients randomized to device for total physical score, physical function, and in physical role limitation compared to control. There were significant differences in the change in total physical score among warfarin naïve and not-warfarin naïve subgroups in the device group compared to control, but larger gains were seen with the warfarin naïve subgroup with a 12 month change of 1.3 ± 8.8 versus -3.6 ± 6.7, p = 0.0004 device compared to warfarin. CONCLUSIONS: Patients with non-valvular AF at risk for stroke treated with LAA closure have favorable QOL changes at 12 mos. vs. patients treated with warfarin.
Oluseun Alli; Shepal Doshi; Saibal Kar; Vivek Reddy; Horst Sievert; Chris Mullin; Vijay Swarup; Brian Whisenant; David Holmes
Related Documents :
6706066 - Course and outcome of chronic pancreatitis. longitudinal study of a mixed medical-surgi...
23175286 - Integration of patient-reported outcome measures with key clinical outcomes after immed...
9529486 - Effect of endoscopic sphincterotomy and interval cholecystectomy on late outcome after ...
2396236 - Massive pleural effusion due to pancreatic pseudocyst.
8006486 - Evaluation of masticatory function after sagittal split ramus osteotomy for patients wi...
1935306 - The role of bronchoscopy in pulmonary complications due to mustard gas inhalation.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-28
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  -     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-3-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
University of Alabama, Birmingham, AL.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Impact of Repeat Myocardial Revascularization on Outcome in Patients with Silent Ischemia after Prev...
Next Document:  Usefulness of intracardiac echocardiography for the diagnosis of cardiovascular implantable electron...