Document Detail


Quality of INR Control and Outcomes Following Venous Thromboembolism.
MedLine Citation:
PMID:  22275390     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Introduction: The objective of this study was to evaluate the pattern of anticoagulation after venous thromboembolism (VTE) in actual clinical practice. Material and Methods: This study used the General Practice Research Database. Individuals aged 18+ years with VTE were matched to 3 controls. Results: Of the 46 335 patients with VTE and 138 024 controls, 70.2% of cases and 86.6% of controls had no obvious risk factors. The mortality risk was increased substantially around the time of diagnosis (relative hazard rate [RR] around 21) but remained elevated for a further 4 years (RRs around 1.5-2.0). The mean percentage of time spent within the therapeutic range for international normalized ratio (INR) was 57.0%. The lowest rate of VTE recurrence occurred in patients with ≥70% time spent within therapeutic range (RR of 0.50, 95% CI 0.39-0.63 compared to <30%). Conclusions: Higher time spent within therapeutic INR range was associated with lower risks of VTE recurrence and death due to VTE.
Authors:
Arlene M Gallagher; Frank de Vries; Jonathan M Plumb; Bastian Haß; Andreas Clemens; Tjeerd-Pieter van Staa
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-23
Journal Detail:
Title:  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis     Volume:  -     ISSN:  1938-2723     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508125     Medline TA:  Clin Appl Thromb Hemost     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
General Practice Research Database, Medicines and Healthcare products Regulatory Agency, London, UK; Utrecht Institute for Pharmaceutical Sciences, Utrecht.
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