| Quality of INR Control and Outcomes Following Venous Thromboembolism. | |
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MedLine Citation:
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PMID: 22275390 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: The objective of this study was to evaluate the pattern of anticoagulation after venous thromboembolism (VTE) in actual clinical practice. Material and Methods: This study used the General Practice Research Database. Individuals aged 18+ years with VTE were matched to 3 controls. Results: Of the 46 335 patients with VTE and 138 024 controls, 70.2% of cases and 86.6% of controls had no obvious risk factors. The mortality risk was increased substantially around the time of diagnosis (relative hazard rate [RR] around 21) but remained elevated for a further 4 years (RRs around 1.5-2.0). The mean percentage of time spent within the therapeutic range for international normalized ratio (INR) was 57.0%. The lowest rate of VTE recurrence occurred in patients with ≥70% time spent within therapeutic range (RR of 0.50, 95% CI 0.39-0.63 compared to <30%). Conclusions: Higher time spent within therapeutic INR range was associated with lower risks of VTE recurrence and death due to VTE. |
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Authors:
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Arlene M Gallagher; Frank de Vries; Jonathan M Plumb; Bastian Haß; Andreas Clemens; Tjeerd-Pieter van Staa |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-23 |
Journal Detail:
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Title: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis Volume: - ISSN: 1938-2723 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508125 Medline TA: Clin Appl Thromb Hemost Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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General Practice Research Database, Medicines and Healthcare products Regulatory Agency, London, UK; Utrecht Institute for Pharmaceutical Sciences, Utrecht. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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