Document Detail

Qualitative and quantitative alterations of cell surface carbohydrate residues during epidermal morphogenesis.
MedLine Citation:
PMID:  15678348     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to investigate the carbohydrate residue composition of cell surface in the developing epidermis and to define the chronological sequence of its alterations in human fetuses from the 10th to the 20th weeks of gestation and at the 23rd week of gestation, using a panel of six biotinylated lectins: Concanavalin A, Ulex europaeus agglutinin-I, Ricinus communis agglutinin-I, Peanut agglutinin, Wheat germ agglutinin, and Dolichos biflorus agglutinin. Distinct qualitative and quantitative alterations in the expression of cell surface carbohydrate residues were found during epidermal morphogenesis prior to keratinization (10th to 20th weeks). At the 23rd week of gestation, the already keratinized fetal human epidermis revealed a pattern of cell surface glycosylation very similar to that of the adult human epidermis. Further studies are now warranted to answer the question regarding whether the glycosylation pattern in the developing human epidermis is disturbed in fetuses with genodermatoses and whether these disturbances might be important for prenatally diagnosing the latter.
E Pasmatzi; G Badavanis; A Monastirli; S Georgiou; A Sagriotis; Th Sakkis; S Mantagos; J Varakis; G Stamatiou; D Tsambaos
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Publication Detail:
Type:  Journal Article     Date:  2005-01-28
Journal Detail:
Title:  Anatomy and embryology     Volume:  209     ISSN:  0340-2061     ISO Abbreviation:  Anat. Embryol.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-15     Completed Date:  2005-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505194     Medline TA:  Anat Embryol (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  207-15     Citation Subset:  IM    
Department of Dermatology, School of Medicine, University of Patras, P.O. Box 1413, 26504 Rio-Patras, Greece.
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MeSH Terms
Carbohydrate Metabolism*
Cell Differentiation / physiology
Cell Membrane / metabolism
Epidermis / embryology*,  metabolism*
Fetal Development
Keratinocytes / cytology,  metabolism
Keratins / metabolism
Membrane Glycoproteins / metabolism*
Organogenesis / physiology
Staining and Labeling
Reg. No./Substance:
0/Lectins; 0/Membrane Glycoproteins; 68238-35-7/Keratins

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