Document Detail


Qualitative assessment of general movements in high-risk preterm infants with chronic lung disease requiring dexamethasone therapy.
MedLine Citation:
PMID:  9506645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The objective of this study was to determine in preterm infants at risk for severe chronic lung disease (1) the quality of general movements (GMs) and (2) the effect of dexamethasone treatment on spontaneous motor activity. STUDY DESIGN: In 15 very low birth weight infants the quality of GMs was assessed from repeated videotape recordings. Recordings were made at weekly intervals during the preterm period until term age and thereafter three times until the twentieth postterm week. All infants required dexamethasone therapy, and additional recordings were made a few hours before and 24 hours, 48 hours, and 7 days after dexamethasone was started. The relationship among movement quality, brain ultrasonographic abnormalities, and long-term outcome was explored. Acute effects of dexamethasone on motor activity were examined. RESULTS: After dexamethasone therapy was started, a significant transient reduction of the quantity of most spontaneous movements (p < 0.05) and a reduction of speed and amplitude of GMs was found (p < 0.05). A significant relationship was found between the severity of brain ultrasonographic abnormalities and the extent to which developmental trajectories of GMs were abnormal (p < 0.001). The development of cerebral palsy was related to the presence of cramped-synchronized movements near term (p < 0.02) and to the absence of fidgety movements at the age of 3 months after term (p < 0.05). CONCLUSION: In preterm infants with severe chronic lung disease and brain lesions, dexamethasone treatment leads to an acute reduction in motility and changes in the speed and amplitude of GMs. Until more is known about long-term neurologic sequelae, a cautious use of systemic dexamethasone therapy in preterm infants is recommended.
Authors:
A F Bos; A Martijn; R M van Asperen; M Hadders-Algra; A Okken; H F Prechtl
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  132     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-04-01     Completed Date:  1998-04-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  300-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Beatrix Children's Hospital, Groningen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Chronic Disease
Dexamethasone / therapeutic use*
Echoencephalography
Female
Glucocorticoids / therapeutic use*
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / drug therapy,  physiopathology*,  ultrasonography
Lung Diseases / drug therapy,  physiopathology*,  ultrasonography
Male
Motor Activity*
Chemical
Reg. No./Substance:
0/Glucocorticoids; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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