Document Detail


Qualitative analysis of proteinuria associated with bladder cancer.
MedLine Citation:
PMID:  87388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present investigation molecular components associated with the urines from bladder cancer patients and normal individuals are identified. Polyacrylamide gels of urines from bladder cancer, bladder papilloma, and normal individual exhibit clear differences in banding patterns. Urine from bladder cancer patients shows gels with increased quantities of low (less than 100,000) and increased and additional high (less than 100,000) molecular weight proteins when compared to gels with urine from papilloma and normal individuals. In order to localize and identify proteins in the urine from bladder cancer, papilloma, and normal individuals, proteins were separately fractionated on Sephadex G-200 columns and each elution fraction was reacted on Ouchterlony gel diffusion against various specific antisera. The qualitative analysis of proteins in urine from bladder cancer patients is discussed in relation to their molecular weight distribution in the Sephadex G-200 profiles and their possible role in tumor host relationships.
Authors:
P O'Brien; J Gozzo; W Cronin; A Monaco
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative urology     Volume:  17     ISSN:  0021-0005     ISO Abbreviation:  Invest Urol     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-09-01     Completed Date:  1979-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374747     Medline TA:  Invest Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  28-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Albuminuria
Chromatography, Gel
Electrophoresis, Polyacrylamide Gel
Fibrinogen / urine
Haptoglobins / urine
Humans
Immunodiffusion
Immunoglobulin A / urine
Immunoglobulin G / urine
Orosomucoid / urine
Proteinuria / diagnosis,  etiology*
Transferrin / urine
Urinary Bladder Neoplasms / complications,  diagnosis*
alpha-Macroglobulins / urine
Chemical
Reg. No./Substance:
0/Haptoglobins; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Orosomucoid; 0/alpha-Macroglobulins; 11096-37-0/Transferrin; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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