Document Detail

Qualitative and quantitative real time myocardial contrast echocardiography for detecting hibernating myocardium.
MedLine Citation:
PMID:  21395665     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Real time myocardial contrast echocardiography (RTMCE) is an emerging imaging modality for assessing myocardial perfusion that allows for noninvasive quantification of regional myocardial blood flow (MBF).
AIM: We sought to assess the value of qualitative analysis of myocardial perfusion and quantitative assessment of myocardial blood flow (MBF) by RTMCE for predicting regional function recovery in patients with ischemic heart disease who underwent coronary artery bypass grafting (CABG).
METHODS: Twenty-four patients with coronary disease and left ventricular systolic dysfunction (ejection fraction <45%) underwent RTMCE before and 3 months after CABG. RTMCE was performed using continuous intravenous infusion of commercially available contrast agent with low mechanical index power modulation imaging. Viability was defined by qualitative assessment of myocardial perfusion as homogenous opacification at rest in ≥2 segments of anterior or ≥1 segment of posterior territory. Viability by quantitative assessment of MBF was determined by receiver-operating characteristics curve analysis.
RESULTS: Regional function recovery was observed in 74% of territories considered viable by qualitative analysis of myocardial perfusion and 40% of nonviable (P = 0.03). Sensitivity, specificity, positive and negative predictive values of qualitative RTMCE for detecting regional function recovery were 74%, 60%, 77%, and 56%, respectively. Cutoff value of MBF for predicting regional function recovery was 1.76 (AUC = 0.77; 95% CI = 0.62-0.92). MBF obtained by RTMCE had sensitivity of 91%, specificity of 50%, positive predictive value of 75%, and negative predictive value of 78%.
CONCLUSION: Qualitative and quantitative RTMCE provide good accuracy for predicting regional function recovery after CABG. Determination of MBF increases the sensitivity for detecting hibernating myocardium.
Daniela Ribeiro Aleixo Fernandes; Jeane Mike Tsutsui; Edimar Alcides Bocchi; Luiz Antônio Machado César; João César Nunes Sbano; José Antonio Franchini Ramires; Wilson Mathias
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Publication Detail:
Type:  Journal Article     Date:  2011-03-14
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  28     ISSN:  1540-8175     ISO Abbreviation:  Echocardiography     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-17     Completed Date:  2011-08-11     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  342-9     Citation Subset:  IM    
Copyright Information:
© 2011, Wiley Periodicals, Inc.
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MeSH Terms
Computer Systems
Contrast Media
Echocardiography / methods*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Middle Aged
Myocardial Stunning / ultrasonography*
Reproducibility of Results
Sensitivity and Specificity
Reg. No./Substance:
0/Contrast Media

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