Document Detail


Qualifying change: a method for defining clinically meaningful outcomes of change score computation.
MedLine Citation:
PMID:  11083327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To identify clinically meaningful change in longitudinal assessment. DESIGN: A novel approach that qualifies item-level change over time by the degree to which it is clinically meaningful. SETTING: The classification method was tested by applying it to changes over 12 months in the frequency ratings of the items of a behavioral assessment instrument that is used commonly in clinical trials with Alzheimer's disease (AD) patients. PARTICIPANTS: Responses from a cohort of 235 well characterized, community-dwelling subjects with AD were analyzed by this method. MEASUREMENTS: The approach allowed us to describe the proportions of items that emerged, ceased, worsened, and improved between the baseline and 12-month visits. RESULTS AND CONCLUSIONS: One-year change in the behavioral symptoms of persons with AD was used to exemplify the methodology. This approach can be used in other populations and with other measurements and was designed for analyses of clinical trial data. This method uses item-level changes to generate global impressions of clinically meaningful change; it also facilitates the definition of change that can be used in the clinical setting.
Authors:
R E Tractenberg; S Jin; M Patterson; L S Schneider; A Gamst; R G Thomas; L J Thal
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American Geriatrics Society     Volume:  48     ISSN:  0002-8614     ISO Abbreviation:  J Am Geriatr Soc     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-11-29     Completed Date:  2000-11-29     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  7503062     Medline TA:  J Am Geriatr Soc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1478-82     Citation Subset:  IM    
Affiliation:
Alzheimer's Disease Cooperative Study, Department of Neurosciences, University of California, San Diego, La Jolla 92093-0949, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / classification,  physiopathology*
Data Interpretation, Statistical
Educational Status
Female
Follow-Up Studies
Geriatric Assessment*
Humans
Male
Outcome Assessment (Health Care)
Time Factors
Grant Support
ID/Acronym/Agency:
AG 10483/AG/NIA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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