| Quadrivalent Ann Arbor strain live attenuated influenza vaccine. | |
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MedLine Citation:
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PMID: 23151111 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Influenza B is responsible for significant morbidity in children and adults worldwide. For more than 25 years, two antigenically distinct lineages of influenza B viruses, B/Yamagata and B/Victoria, have cocirculated globally. Current influenza vaccine formulations are trivalent and contain two influenza subtype A strains (A/H1N1 and A/H3N2) but only one B strain. In a half of recent influenza seasons, the predominant circulating influenza B lineage was different from that contained in trivalent influenza vaccines. A quadrivalent live attenuated influenza vaccine (Q/LAIV) that contains two B strains, one from each lineage, has been developed to help provide broad protection against influenza B. Q/LAIV was recently approved for use in the USA in eligible individuals 2-49 years of age. This review summarizes clinical trial data in support of Q/LAIV. |
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Authors:
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Seth L Toback; Myron J Levin; Stan L Block; Robert B Belshe; Christopher S Ambrose; Judith Falloon |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-14 |
Journal Detail:
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Title: Expert review of vaccines Volume: - ISSN: 1744-8395 ISO Abbreviation: Expert Rev Vaccines Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101155475 Medline TA: Expert Rev Vaccines Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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MedImmune, LLC, Gaithersburg, MD, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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