Document Detail


Quadrivalent Ann Arbor strain live attenuated influenza vaccine.
MedLine Citation:
PMID:  23151111     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Influenza B is responsible for significant morbidity in children and adults worldwide. For more than 25 years, two antigenically distinct lineages of influenza B viruses, B/Yamagata and B/Victoria, have cocirculated globally. Current influenza vaccine formulations are trivalent and contain two influenza subtype A strains (A/H1N1 and A/H3N2) but only one B strain. In a half of recent influenza seasons, the predominant circulating influenza B lineage was different from that contained in trivalent influenza vaccines. A quadrivalent live attenuated influenza vaccine (Q/LAIV) that contains two B strains, one from each lineage, has been developed to help provide broad protection against influenza B. Q/LAIV was recently approved for use in the USA in eligible individuals 2-49 years of age. This review summarizes clinical trial data in support of Q/LAIV.
Authors:
Seth L Toback; Myron J Levin; Stan L Block; Robert B Belshe; Christopher S Ambrose; Judith Falloon
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  Expert review of vaccines     Volume:  -     ISSN:  1744-8395     ISO Abbreviation:  Expert Rev Vaccines     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101155475     Medline TA:  Expert Rev Vaccines     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
MedImmune, LLC, Gaithersburg, MD, USA.
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