Document Detail

QTc interval prolongation during infusion with dipyridamole or adenosine.
MedLine Citation:
PMID:  7744540     Owner:  NLM     Status:  MEDLINE    
The aim of our study was to discover whether there was a relationship between the QTc interval prolongation on the standard 12-lead electrocardiogram (ECG) and provoked myocardial ischemia. Since the increase of adenosine plasma levels, obtained either with adenosine or dipyridamole (an adenosine reuptake inhibitor) infusion, has been used to test the coronary artery reserve in patients affected by coronary artery disease, the QTc interval modifications during dipyridamole or adenosine echocardiographic stress test were evaluated. Twenty-five patients admitted to our Institute for evaluation of chest pain of suspected myocardial origin underwent an echocardiographic dipyridamole stress test (0.84 mg/kg over 10 min) after discontinuation of antianginal treatment. Of these patients, 10 underwent an echocardiographic adenosine stress test (scalar doses of 50, 75, 100, 140 micrograms/kg/min) after 48-72 h. The Bazett formula was used to evaluate the QTc interval. After dipyridamole and adenosine administration, a significant prolongation of the QTc interval was observed only in those patients who had positive test results. Our data suggested that QTc interval prolongation during pharmacological stress tests might be considered a marker of myocardial ischemia.
F Guideri; D Ferber; G Galgano; S Isidori; P Blardi; F L Pasini; T Di Perri
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  48     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-06-09     Completed Date:  1995-06-09     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  67-73     Citation Subset:  IM    
Institute of Clinical Medicine, School of Medicine, University of Siena, Italy.
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MeSH Terms
Adenosine / administration & dosage*
Blood Pressure / drug effects
Dipyridamole / administration & dosage*
Echocardiography / drug effects*
Exercise Test / methods*
Heart Conduction System / drug effects*,  physiology
Heart Rate / drug effects
Middle Aged
Myocardial Ischemia / diagnosis*,  physiopathology
Ventricular Function, Left / drug effects
Reg. No./Substance:
58-32-2/Dipyridamole; 58-61-7/Adenosine

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