| QTc Interval and QT Dispersion in Patients with Thalassemia Major: Electrocardiographic (EKG) and Echocardiographic Evaluation. | |
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MedLine Citation:
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PMID: 20567638 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Doppler echocardiographic studies in patients with beta-Thalassemia Major (beta-TM) had shown different patterns of left ventricle (LV) systolic and diastolic dysfunctions. AIM: This cross-sectional study was designed to study the LV systolic and diastolic function in patients with beta-TM using Pulsed Doppler (PD) Echocardiogram and assess the QTc interval and QT dispersion (QTd) on 12 leads ECG. METHOD: All patients were evaluated clinically as well as by echocardiography and 12 leads ECG. The study included patients with beta-TM (n = 38, age 15.7 +/- 8.9 years), compared with an age-matched healthy control group (n = 38, age 15.9 +/- 8.9 years). RESULTS: In 38 patients with beta-TM Compared with healthy control group, The QTc interval and the QTd dispersion on ECG were increased with no significant difference mode echo showed that beta-TM patients have thicker LV septal wall index (0.659 +/- 0.23 vs. 0.446 +/- 0.219 cm/M(2), P < 0.001), posterior wall index (0.659 +/- 0.235 vs. 0.437 +/- 0.214 cm/M(2), P < 0.01), and larger LVEDD index is (3.99 +/- 0.48 vs. 2.170 +/- 0.57 cm/M(2). P < 0.05). Pulsed Doppler showed high LV trans-mitral E wave velocity index (70.818 +/- 10.139 vs. 57.532 +/- 10.139, P < 0.05) and E/A ratio (1.54 vs.1.23, P < 0.01). The duration of deceleration time index (DT) and isovolumic relaxation time index (IVRT) were significantly shorter in patients with beta-TM (150.234 +/- 20.0.23 vs. 167.123 +/- 167.123 +/- 19.143 msec/M(2), P < 0.01) and (60.647 +/- 6.77 vs. 75.474 +/- 5.83 msec/M(2), P < 0.001), respectively. The tricuspid valve velocity in patients with beta-TM was significantly higher than controls (2.993 +/- 0.569 vs. 1.93 +/- 0.471 m/sec, respectively, P < 0.01), with calculated pulmonary artery pressure of 2.4 times the control (36.0 vs. 14.8 mmHg). However, the LVEF% or fractional shortening were not significantly different. CONCLUSION: In this study, beta-thalassemia major patients compared with controls have differences of QT dispersion and corrected QT interval that is of no statistical significance. A significantly thicker LV wall and LV diastolic filling indices are suggestive of restrictive diastolic pattern. These data indicate that LV diastolic abnormalities compromised initially in patients with beta-thalassemia major. |
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Authors:
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Taysir S Garadah; Salah Kassab; Najat Mahdi; Ahmed Abu-Taleb; Anwer Jamsheer |
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Publication Detail:
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Type: Journal Article Date: 2010-03-18 |
Journal Detail:
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Title: Clinical Medicine Insights. Cardiology Volume: 4 ISSN: 1179-5468 ISO Abbreviation: Clin Med Insights Cardiol Publication Date: 2010 |
Date Detail:
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Created Date: 2010-06-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101525768 Medline TA: Clin Med Insights Cardiol Country: New Zealand |
Other Details:
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Languages: eng Pagination: 31-7 Citation Subset: - |
Affiliation:
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Cardiac Unit, Salmaniya Medical Complex, Ministry of Health, Kingdom of Bahrain. |
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