Document Detail


QTc interval and neurological outcomes in aneurysmal subarachnoid hemorrhage.
MedLine Citation:
PMID:  20652444     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Prolonged heart rate-corrected QT (QTc) interval is frequently observed in subarachnoid hemorrhage (SAH). This study was conducted to determine the relationship between QTc interval and neurological outcome during the acute posthemorrhagic period after aneurysmal SAH.
METHODS: We studied 71 patients undergoing surgery who were admitted within 24 h after the onset of aneurysmal SAH. Standard 12-lead electrocardiography was performed on admission (T1) and at 1 and 7 days after operation (T2 and T3). QT intervals were corrected by heart rate according to the Fridericia formula. The Glasgow Coma Scale (GCS) score was calculated over the period T1-T3. Neurological outcome was assessed using the Glasgow Outcome Scale at hospital discharge.
RESULTS: Among the 71 patients, 31 had an unfavorable neurological outcome. Although QTc interval prolongation improved in patients with a good outcome, QTc interval prolongation continued in patients with an unfavorable outcome. The areas under the receiver-operator characteristic curves showed that the QTc and GCS score at T3, and the Hunt and Hess grade were significant predictors of an unfavorable neurological outcome. The threshold value, sensitivity, and specificity for the QTc at T3 were 448 ms, 73% [95% confidence interval (CI), 68-78], and 93% (95% CI, 90-96), respectively.
CONCLUSION: This study confirms that QTc interval prolongation continues in the SAH patients with an unfavorable outcome but that QTc interval prolongation improves in patients with a good outcome, suggesting that a QTc interval of more than 448 ms at 7 days after operation is a predictor of neurological outcome after SAH.
Authors:
Taiga Ichinomiya; Yoshiaki Terao; Kosuke Miura; Ushio Higashijima; Tomomi Tanise; Makoto Fukusaki; Koji Sumikawa
Related Documents :
20382494 - Preoperative statin therapy is associated with improved outcomes and resource utilizati...
24959934 - The influence of body mass index and weight loss on outcome of elderly patients undergo...
24217704 - Low levels of low-density lipoprotein cholesterol: a negative predictor of survival in ...
23674854 - Trans-arterial chemo-embolization is safe and effective for very elderly patients with ...
25187754 - Replacement of anesthesia machines improves intraoperative ventilation parameters assoc...
24257904 - Outcomes of pediatric appendicitis: an international comparison of the united states an...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurocritical care     Volume:  13     ISSN:  1556-0961     ISO Abbreviation:  Neurocrit Care     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101156086     Medline TA:  Neurocrit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  347-54     Citation Subset:  IM    
Affiliation:
Department of Anesthesia, Nagasaki Rosai Hospital, 2-12-5 Setogoe, Sasebo, 857-0134, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Intracortical EEG for the detection of vasospasm in patients with poor-grade subarachnoid hemorrhage...
Next Document:  Evaluation of coma: a critical appraisal of popular scoring systems.