Document Detail


QTc dispersion in hyperthyroidism and its association with pulmonary hypertension.
MedLine Citation:
PMID:  19335859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Several studies have reported that hyperthyroidism is associated with prolonged QT interval corrected by the heart rate (QTc) and pulmonary hypertension (PHT). METHODS: Forty-seven patients with newly diagnosed overt hyperthyroidism and 20 healthy people were enrolled in the study. Transthoracic echocardiography, 12-lead surface electrocardiogram, and thyroid hormone levels were studied at the time of enrollment and after achievement of euthyroid state with propylthiouracil treatment. RESULTS: Baseline clinical characteristics were similar. However, heart rate (90.5+/-19.6 vs 79.2+/-13.7 bpm, P = 0.024), pulmonary artery systolic pressure (PASP) (26.0+/-12.0 vs 10.6+/-4.0 mmHg, P < 0.001), E deceleration time (DT) (191.8+/-25.6 vs 177.0+/-10.7 ms, P = 0.016), isovolumetric relaxation time (IVRT) (91.38+/-12.3 vs 79.6+/-10.5 ms, P < 0.001), and QTc dispersion (QTcD) (50.3+/-17.2 vs 38.9+/-11.6 ms, P = 0.009) were significantly higher in hyperthyroid patients compared to control group. Heart rate (to 74.1+/-13.8, P < 0.001), QTcD (to 37.3+/-10.1 ms, P < 0.001), DT (to 185.3+/-19.7 ms, P = 0.008), IVRT (to 88.6+/-10.3 ms, P = 0.056), and PASP (23.1+/-10.1 mmHg P < 0.001) were significantly decreased after achievement of euthyroid state. Although PHT was present in 16 patients before treatment only six patients still had PHT during euyhyroid state. Compared to patients with normal PASP, QTcD was significantly longer in patients with PHT (56.5+/-15.8 vs 37.9+/-12.8 mmHg P < 0.001). There were also significant correlations between QTcD and presence of PHT (r = 0.516, P < 0.001) and PASP (r = 0.401, P = 0.009). CONCLUSIONS: Hyperthyroidism is a reversible cause of PHT and diastolic dysfunction. Increased QTcD observed in hyperthyroidism may be associated with PHT and diastolic dysfunction. These abnormal findings in hyperthyroidism often normalize with the achievement of euthyroid state.
Authors:
Unal Guntekin; Yilmaz Gunes; Mustafa Tuncer; Hakki Simsek; Hasan Ali Gumrukcuoglu; Sevket Arslan; Ahmet Gunes
Related Documents :
2484879 - Transient hypothyroidism after iodine-131 treatment of graves' disease.
18716489 - Hyperthyroidism as a cause of autonomic dysreflexia.
18302519 - The prevalence of transient thyrotoxicosis after antithyroid drug therapy in patients w...
7396599 - Clinical hyperthyroidism in a patient receiving long-term hemodialysis.
10365679 - Transition of nodular toxic goiter to autoimmune hyperthyroidism triggered by 131i ther...
6426529 - Persistent neuroendocrine dysregulation in major depressive disorder: a marker for earl...
20949239 - Open comparison study of oxidative stress markers between patients with chronic renal f...
22992599 - Multifocal micronodular pneumocyte hyperplasia: computed tomographic appearance and fol...
16922979 - Independence/dependence--a contradictory relationship? life with a chronic illness.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  32     ISSN:  1540-8159     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-01     Completed Date:  2009-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  494-9     Citation Subset:  IM    
Affiliation:
Yuzuncu Yil University, Faculty of Medicine, Cardiology Department, Van, Turkey. guntekinunal@hotmail.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Female
Heart Rate*
Humans
Hypertension, Pulmonary / complications,  diagnosis*,  physiopathology*
Hyperthyroidism / complications,  diagnosis*,  physiopathology*
Long QT Syndrome / complications,  diagnosis*,  physiopathology*
Male

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Analysis of atrioventricular nodal reentrant tachycardia with variable ventriculoatrial block: chara...
Next Document:  Predictors of Atrial Tachyarrhythmias in Subjects with Type 1 ECG Pattern of Brugada Syndrome.