Document Detail

A QTL on pig chromosome 4 affects fatty acid metabolism: evidence from an Iberian by Landrace intercross.
MedLine Citation:
PMID:  11048916     Owner:  NLM     Status:  MEDLINE    
Three Iberian boars were bred to 31 Landrace sows to produce 79 F1 pigs. Six F1 boars were mated to 73 F1 sows. The F2 progeny from 33 full-sib families (250 individuals) were genotyped for seven microsatellites spanning the length of chromosome 4. Least squares procedures for interval mapping were used to detect quantitative trait loci (QTL). A permutation test was used to establish nominal significance levels associated with QTL effects, and resulting probability levels were corrected to a genomewide basis. Observed QTL effects were (genomewide significance, position of maximum significance in centimorgans): percentage of linoleic acid in subcutaneous adipose tissue (< 0.01, 81); backfat thickness (< 0.01, 83); backfat weight (< 0.01, 80); longissimus muscle area (0.02, 83); live weight (0.19, 88); and percentage of oleic acid in subcutaneous adipose tissue (0.25, 81). Gene action was primarily additive. The Iberian genotypes were fatter, slower growing, and had lower linoleic and higher oleic acid contents than Landrace genotypes. The interval from 80 to 83 cM contains the FAT1 and A-FABP loci that have been shown previously to affect fat deposition in pigs. This is the first report of a QTL affecting fatty acid composition of subcutaneous adipose tissue in pigs and provides a guide for the metabolic pathways affected by candidate genes described in this region of chromosome 4.
M Pérez-Enciso; A Clop; J L Noguera; C Ovilo; A Coll; J M Folch; D Babot; J Estany; M A Oliver; I Díaz; A Sánchez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of animal science     Volume:  78     ISSN:  0021-8812     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-12-19     Completed Date:  2000-12-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2525-31     Citation Subset:  IM    
Area de Producció Animal, Centre UdL-IRTA, Lleida, Spain.
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MeSH Terms
Adipose Tissue / metabolism
Body Weight
Chromosome Mapping / veterinary
Fatty Acids / metabolism*
Hybridization, Genetic
Quantitative Trait, Heritable*
Swine / classification,  genetics*,  metabolism
Reg. No./Substance:
0/Fatty Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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