Document Detail

QT interval prolongation in future SIDS victims: a polysomnographic study.
MedLine Citation:
PMID:  19090325     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Previous data have suggested that a prolonged QTc interval during the first days of life can be associated with some cases of sudden infant death syndrome (SIDS). Analysis of heart rate variability during sleep in future SIDS victims has shown findings compatible with an imbalance in autonomic tone. We hypothesized that some future SIDS infants could have longer QTc intervals during sleep, compared with healthy control infants, and that this difference would correlate with the autonomic imbalance already found in these infants.
METHODS: QTc intervals and a heart rate autoregressive power spectral analysis were calculated during the same periods in the polysomnographic sleep recordings of 18 infants who eventually died of SIDS and of 18 control infants. The control infants were matched for sex, gestational age, postnatal age, birth weight, and sleep position. The median postnatal age was 8 weeks.
RESULTS: Compared with control infants, future SIDS victims were characterized by having longer QTc intervals during total sleep (P = 0.019), rapid eye movement sleep (P = 0.045) and non-rapid eye movement sleep (P = 0.029). When the night was divided into 3 equal parts, this difference was always present but was most marked during the last part of the night. There was, respectively, a negative and a positive correlation between parasympathetic activity and sympathovagal balance and median and maximum QTc interval values.
CONCLUSION: Compared with QTc intervals in matched control infants, QTc intervals were increased in future SIDS victims. Such a prolongation could be related to the autonomic dysfunction already reported in these patients.
Patricia Franco; José Groswasser; Sonia Scaillet; Jean-Pol Lanquart; Abraham Benatar; Jean-Pierre Sastre; Philippe Chevalier; Béatrice Kugener; André Kahn; Jian-Sheng Lin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Sleep     Volume:  31     ISSN:  0161-8105     ISO Abbreviation:  Sleep     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-18     Completed Date:  2009-02-09     Revised Date:  2011-05-17    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1691-9     Citation Subset:  IM    
Pediatric Sleep Unit, Hôpital M&re-Enfant & INSERM-U628, University Lyon, Lyon, France.
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MeSH Terms
Autonomic Nervous System / physiopathology
Fourier Analysis
Heart Rate / physiology
Long QT Syndrome / diagnosis*,  physiopathology
Risk Factors
Signal Processing, Computer-Assisted
Sudden Infant Death / diagnosis,  etiology*

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