Document Detail

QT interval dispersion: a non-invasive marker of susceptibility to arrhythmia in patients with sustained ventricular arrhythmias?
MedLine Citation:
PMID:  8043329     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess QT interval dispersion on the surface electrocardiogram in patients with sustained ventricular arrhythmias. DESIGN: A retrospective and prospective blinded controlled study of patients referred for investigation of ventricular arrhythmias at a tertiary cardiac centre. PATIENTS AND METHODS: 89 consecutive patients with sustained ventricular arrhythmias due to chronic ischaemic heart disease, cardiomyopathy, or ventricular tachycardia (VT) in a normal heart. 32 patients did not meet the inclusion criteria; therefore 57 patients were compared with a control group of 40 patients with myocardial disease but no history of arrhythmias and 12 normal controls with no myocardial disease. Standard 12 lead electrocardiograms were enlarged, the QT intervals for each lead measured, and QT dispersion calculated. RESULTS: There was a significantly greater mean QT dispersion (77 ms) in patients with sustained ventricular arrhythmias compared with the control group (38 ms, p < 0.01). This held for all groups; after myocardial infarction VT (82 (22) ms v control 38 (10) ms; p < 0.01), dilated cardiomyopathy VT (76 (18) ms v control 40 (11) ms, p < 0.01), and normal heart VT (65 (7) ms v control 32 (8), p < 0.05). There was also a greater QT dispersion in patients with impaired left ventricular function and VT, with a correlation between left ventricular function and QT dispersion in patients with VT (r = 0.56, p < 0.01). CONCLUSION: QT interval dispersion may be a further non-invasive marker of susceptibility to ventricular arrhythmias.
M Pye; A C Quinn; S M Cobbe
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  71     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-09-01     Completed Date:  1994-09-01     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  511-4     Citation Subset:  AIM; IM    
Department of Cardiology, Royal Infirmary, Glasgow, Scotland.
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MeSH Terms
Arrhythmias, Cardiac / physiopathology
Cardiomyopathy, Dilated / physiopathology
Disease Susceptibility
Heart / physiopathology*
Middle Aged
Myocardial Infarction / physiopathology
Prospective Studies
Retrospective Studies
Tachycardia, Ventricular / physiopathology*
Ventricular Fibrillation / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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