Document Detail

QT interval analysis in patients with acute biliary pancreatitis.
MedLine Citation:
PMID:  16163055     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has been previously proposed that electrocardiographic abnormalities may be associated with acute pancreatitis. However, there is a lack of data on the QT interval and dispersion value in patients with acute pancreatitis, and no data are also available concerning QT interval and QT dispersion in acute biliary pancreatitis (ABP). AIMS:: We aimed to investigate the QT parameters in patients with ABP, to compare them with those of healthy controls, and to analyze the relationship between QT parameters and Ranson score. METHODS: The present study included 32 patients with acute biliary pancreatitis and 35 healthy controls. The severity of the pancreatitis was determined by Atlanta criteria: fewer than 3 Ranson criteria or fewer than 8 APACHE II (the Acute Physiology and Chronic Health Evaluation) points indicated the mild disease (group 1); 3 or more Ranson criteria or 8 or more APACHE II points or organ failure or systemic complications or local complications indicated the severe disease (group 2). On admission, all patients underwent a standard 12-lead electrocardiogram, and corrected maximum QTc interval (QTcmax), corrected minimum QT interval (QTcmin), and corrected QTc dispersion (QTcd) values of the subjects were measured according to the Bazett formula in this study. RESULTS: QTcmax and QTcd were significantly longer in patients with ABP than in healthy controls (442 +/- 38 milliseconds versus 413 +/- 34 milliseconds, P < 0.05; and 67 +/- 21 milliseconds versus 42 +/- 18 milliseconds, P < 0.001, respectively). Similarly, QTcmax and QTcd were significantly longer in group 2 than in group 1 (440 +/- 38 milliseconds versus 450 +/- 34 milliseconds, P < 0.01; and 66 +/- 9 milliseconds versus 71 +/- 11 milliseconds, P < 0.01, respectively). Correlation analysis showed that there is a significant positive relationship between Ranson scores of patients and QTcmax and QTcd (P < 0.01 and P < 0.001, respectively). CONCLUSION: The effect of acute biliary pancreatitis on QT intervals and dispersion appears to be dependent not only on the disease but also on its severity, and these parameters may give additional prognostic information in ABP patients, even in the initial evaluation.
Fehmi Ates; Feridun Kosar; Yuksel Aksoy; Bülent Yildirim; Ibrahim Sahin; Fatih Hilmioglu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pancreas     Volume:  31     ISSN:  1536-4828     ISO Abbreviation:  Pancreas     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-15     Completed Date:  2006-03-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  United States    
Other Details:
Languages:  eng     Pagination:  238-41     Citation Subset:  IM    
Department of Internal Medicine, Inonu University, Faculty of Medicine, Turgut Ozal Medical Center, Malatya, Turkey.
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MeSH Terms
Acute Disease
Biliary Tract Diseases / complications*
Long QT Syndrome / etiology*
Middle Aged
Pancreatitis / complications*
Prospective Studies
Severity of Illness Index

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