| QT interval of the ECG, heart rate and arterial pressure during anaesthetic induction: comparative effects of alfentanil and esmolol. | |
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MedLine Citation:
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PMID: 7484039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a double-blind study the effect of esmolol and alfentanil on the QT interval of the ECG corrected by the heart rate (QTc), heart rate and arterial pressure during anaesthetic induction was studied in 59 oxycodone- and atropine-premedicated ASA class I-(II) patients with a mean age of 26 yr (range 15-50 yr). The patients were randomly allocated to one of the four groups: saline, esmolol 2 mg.kg-1, esmolol 3 mg.kg-1 or alfentanil 0.03 mg.kg-1. Both doses of esmolol prevented the prolongation of the QTc interval after thiopental and suxamethonium, but not after laryngoscopy and intubation. Alfentanil prevented the prolongation of the QTc interval following thiopental, suxamethonium and laryngoscopy but not after intubation. Esmolol did not prevent the increase in the heart rate and arterial pressure in response to laryngoscopy and intubation. No cardiovascular responses to laryngoscopy and intubation occurred in the patients treated with alfentanil. No cardiac arrhythmias occurred in the esmolol 3 mg.kg-1 group, whereas the frequency of ventricular ectopic beats was 40% in the saline group and 13-20% in the other groups. |
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Authors:
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R Korpinen; L Saarnivaara; K Siren |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 39 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-12-04 Completed Date: 1995-12-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 809-13 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia, Otolaryngological Hospital, Helsinki University Central Hospital, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adrenergic beta-Antagonists / adverse effects, pharmacology* Adult Alfentanil / adverse effects, pharmacology* Anesthesia* Anesthetics, Intravenous / adverse effects, pharmacology* Arrhythmias, Cardiac / chemically induced Blood Pressure / drug effects* Double-Blind Method Electrocardiography / drug effects* Heart Rate / drug effects* Humans Intubation, Intratracheal Laryngoscopy Middle Aged Propanolamines / adverse effects, pharmacology* Succinylcholine / pharmacology Thiopental / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Anesthetics, Intravenous; 0/Propanolamines; 306-40-1/Succinylcholine; 71195-58-9/Alfentanil; 76-75-5/Thiopental; 84057-94-3/esmolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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