Document Detail

QT dispersion and left ventricular hypertrophy in elderly hypertensive and normotensive patients.
MedLine Citation:
PMID:  18388029     Owner:  NLM     Status:  MEDLINE    
Inhomogeneity of ventricular repolarization as detected by QT dispersion may be a potential leading mechanism of sudden death in hypertensive and normotensive (age related) left ventricular hypertrophy. Aim of this study was to investigate QT dispersion, ventricular arrhythmias, and left ventricular mass index in elderly hypertensive and normotensive patients. Study population consisted of 60 consecutive patients (sex: 34 men/26 women; age: 63 +/- 11 years) with essential arterial hypertension and 48 age and sex-matched control subjects (24 men/24 women; 64 +/- 16 years). Measurements included QTc dispersion, ventricular arrhythmias, and left ventricular hypertrophy. Hypertensive patients had greater left ventricular mass index (P = .006) and higher QTc dispersion (P = .004) than controls. Left ventricular hypertrophy was diagnosed in 57 (31 men/26 women) of all subjects. These patients had higher blood pressure (P < .05), Lown's score (P < .001), and QTc dispersion (P < .001). QTc dispersion and Lown's score were independent predictors of left ventricular mass index (P < .001). Conclusively, QTc dispersion is a strong indicator of left ventricular mass index and might be used in risk stratification of hypertensive and normotensive elderly patients.
Stavros Dimopoulos; Franco Nicosia; Paolo Donati; Paola Prometti; Massimiliano De Vecchi; Roberto Zulli; Vittorio Grassi
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Publication Detail:
Type:  Journal Article     Date:  2008-04-02
Journal Detail:
Title:  Angiology     Volume:  59     ISSN:  1940-1574     ISO Abbreviation:  Angiology     Publication Date:    2008 Oct-Nov
Date Detail:
Created Date:  2008-10-21     Completed Date:  2008-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  605-12     Citation Subset:  IM    
Department of Clinical Therapeutics, Alexandra Hospital, University of Athens, Athens, Greece.
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MeSH Terms
Case-Control Studies
Heart Ventricles / ultrasonography
Hypertension / physiopathology*
Hypertrophy, Left Ventricular / physiopathology*
Middle Aged
Ventricular Premature Complexes / physiopathology

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