Document Detail

QT dispersion in infants with apparent life-threatening events syndrome.
MedLine Citation:
PMID:  12530492     Owner:  NLM     Status:  MEDLINE    
Apparent life-threatening event (ALTE) is a term used to define an event of unknown cause after an infant is found limp, cyanotic, bradycardic, and/or requires resuscitation. Eight to 15% of children with ALTE die of sudden infant death syndrome. Obstructive sleep apnea, bradycardia, gastroesophageal reflux, and laryngotracheal abnormalities are frequently associated with ALTE. Wide QT dispersion is associated with sudden death in heart failure and increased risk of ventricular fibrillation in acute myocardial infarction. Here, we assess QT dispersion in infants with ALTE and its correlation to clinical and electrocardiographic indices. The study included eighty nine infants (age 2.14 +/- 1.8 months, 46 males and 43 females) referred with ALTE to the pediatric emergency room and 18 controls (age 2.77 +/- 2.2 months) who underwent electrocardiogram assessment of QTmin, QTmax, QT dispersion (QT-D), and as well as QTmin, QTmax, and QT-D corrected for heart rate (QTcmin, QTcmax, QTC-D, respectively). All infants were referred at the usual diagnostic tests-the gastroesophageal reflux test, apnea monitoring, Holter ECG monitoring, electroencephalogram, and Doppler echocardiography. QT-D, QTc-D, and QTc-min were significantly greater in the ALTE group (p < 0.01). Greater QTc-D was found in males compared to females (p < 0.001). QT-D and QTc-D showed little or no correlation with age of infant or positivity of diagnostic tests. QTc has been found by multiple regression analysis to be the independent variable with the greatest impact on QTc-D (beta = -0.68, p < 0.001).
E I Goldhammer; G Zaid; V Tal; M Jaffe; E G Abinader
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Pediatric cardiology     Volume:  23     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    2002 Nov-Dec
Date Detail:
Created Date:  2003-01-17     Completed Date:  2003-02-21     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  605-7     Citation Subset:  IM    
Department of Cardiology, Bnai-Zion Medical Center, Haifa 31048, Israel.
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MeSH Terms
Cause of Death
Echocardiography, Doppler
Electrocardiography, Ambulatory*
Heart Rate / physiology
Infant Welfare
Infant, Newborn
Long QT Syndrome / diagnosis*,  physiopathology
Severity of Illness Index
Sex Factors
Statistics as Topic
Sudden Infant Death / etiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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