Document Detail


QT dispersion and electrical heart field morphology in patients treated with dosulepin.
MedLine Citation:
PMID:  15311996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to detect the changes of QT dispersion (QTd) due to cardiotoxicity of tricyclic antidepressant dosulepin. Electrocardiographic and vectorcardiographic recordings were obtained using Cardiag 112.2 diagnostic system from 28 psychiatric outpatients treated with prophylactic doses of dosulepin and compared to those obtained from 37 healthy volunteers. From these recordings following parameters were evaluated: QTd, spatial QRS-STT angle and amplitude of T-wave. The acquired data were correlated with the dosulepin plasma levels using Spearman's rank order correlation test. The average QTd (+/-S.D.) in the dosulepin group was significantly higher (70+/-21 ms) than that in the control group (34+/-12 ms) (P<0.001). Moreover, the correlation between QTd and the dosulepin plasma levels was highly significant (r = 0.7871, P<0.001). Similar results were obtained when QTc dispersion was used. On the contrary, the QRS-STT space angle did not correlate with the dosulepin plasma levels. Furthermore, the T-wave amplitude was not significantly correlated to the QT-interval. Thus we can conclude that the QT dispersion could be used as a simple marker of the dosulepin effect on the myocardium.
Authors:
O Kittnar; I Paclt; M Mlcek; J Slavícek; A Dohnalová; S Havránek; E Brizman; E Kitzlerová; K Pisvejcová
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  53     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2004  
Date Detail:
Created Date:  2004-08-17     Completed Date:  2005-02-11     Revised Date:  2008-04-02    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  379-86     Citation Subset:  IM    
Affiliation:
Institute of Physiology, First Medical Faculty, Charles University, Albertov 5, 128 00 Prague 2, Czech Republic. okittnar@lf1.cuni.cz
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MeSH Terms
Descriptor/Qualifier:
Adult
Depressive Disorder / blood,  drug therapy
Dothiepin / adverse effects*,  blood,  therapeutic use
Electrocardiography / methods*
Female
Heart Rate / drug effects,  physiology
Humans
Long QT Syndrome / blood,  chemically induced*,  physiopathology
Male
Middle Aged
Statistics, Nonparametric
Chemical
Reg. No./Substance:
113-53-1/Dothiepin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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