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QT Interval Heterogeneities Induced Through Local Epicardial Warming/Cooling. An Experimental Study.
MedLine Citation:
PMID:  25432709     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION AND OBJECTIVES: Abnormal QT interval durations and dispersions have been associated with increased risk of ventricular arrhythmias. The present study examines the possible arrhythmogenic effect of inducing QT interval variations through local epicardial cooling and warming.
METHODS: In 10 isolated rabbit hearts, the temperatures of epicardial regions of the left ventricle were modified in a stepwise manner (from 22°C to 42°C) with simultaneous electrogram recording in these regions and in others of the same ventricle. QT and activation-recovery intervals were determined during sinus rhythm, whereas conduction velocity and ventricular arrhythmia induction were determined during programmed stimulation.
RESULTS: In the area modified from baseline temperature (37°C), the QT (standard deviation) was prolonged with maximum hypothermia (195 [47] vs 149 [12] ms; P<.05) and shortened with hyperthermia (143 [18] vs 152 [27] ms; P<.05). The same behavior was displayed for the activation-recovery interval. The conduction velocity decreased with hypothermia and increased with hyperthermia. No changes were seen in the other unmodified area. Repetitive responses were seen in 5 experiments, but no relationship was found between their occurrence and hypothermia or hyperthermia (P>.34).
CONCLUSIONS: In the experimental model employed, local variations in the epicardial temperature modulate the QT interval, activation-recovery interval, and conduction velocity. Induction of heterogeneities did not promote ventricular arrhythmia occurrence.
Antonio Guill; Alvaro Tormos; José Millet; Eduardo J Roses; Antonio Cebrián; Luis Such-Miquel; Luis Such; Manuel Zarzoso; Antonio Alberola; Francisco J Chorro
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Publication Detail:
Type:  Journal Article     Date:  2014-08-04
Journal Detail:
Title:  Revista española de cardiología (English ed.)     Volume:  67     ISSN:  1885-5857     ISO Abbreviation:  Rev Esp Cardiol (Engl Ed)     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101587954     Medline TA:  Rev Esp Cardiol (Engl Ed)     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  993-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Sociedad Española de Cardiología. Published by Elsevier Espana. All rights reserved.
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