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QT Interval Heterogeneities Induced Through Local Epicardial Warming/Cooling. An Experimental Study.
MedLine Citation:
PMID:  25103461     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION AND OBJECTIVES: Abnormal QT interval durations and dispersions have been associated with increased risk of ventricular arrhythmias. The present study examines the possible arrhythmogenic effect of inducing QT interval variations through local epicardial cooling and warming.
METHODS: In 10 isolated rabbit hearts, the temperatures of epicardial regions of the left ventricle were modified in a stepwise manner (from 22°C to 42°C) with simultaneous electrogram recording in these regions and in others of the same ventricle. QT and activation-recovery intervals were determined during sinus rhythm, whereas conduction velocity and ventricular arrhythmia induction were determined during programmed stimulation.
RESULTS: In the area modified from baseline temperature (37°C), the QT (standard deviation) was prolonged with maximum hypothermia (195 [47] vs 149 [12] ms; P<.05) and shortened with hyperthermia (143 [18] vs 152 [27] ms; P<.05). The same behavior was displayed for the activation-recovery interval. The conduction velocity decreased with hypothermia and increased with hyperthermia. No changes were seen in the other unmodified area. Repetitive responses were seen in 5 experiments, but no relationship was found between their occurrence and hypothermia or hyperthermia (P>.34).
CONCLUSIONS: In the experimental model employed, local variations in the epicardial temperature modulate the QT interval, activation-recovery interval, and conduction velocity. Induction of heterogeneities did not promote ventricular arrhythmia occurrence. Full English text available from: www.revespcardiol.org/en.
Authors:
Antonio Guill; Alvaro Tormos; José Millet; Eduardo J Roses; Antonio Cebrián; Luis Such-Miquel; Luis Such; Manuel Zarzoso; Antonio Alberola; Francisco J Chorro
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-4
Journal Detail:
Title:  Revista espanola de cardiologia     Volume:  -     ISSN:  1579-2242     ISO Abbreviation:  Rev Esp Cardiol     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404277     Medline TA:  Rev Esp Cardiol     Country:  -    
Other Details:
Languages:  ENG; SPA     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Sociedad Española de Cardiología. Publicado por Elsevier España. All rights reserved.
Vernacular Title:
Heterogeneidades inducidas en el intervalo QT mediante enfriamiento/calentamiento epicárdico local. Estudio experimental.
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