| QSAR study of antimycobacterial activity of quaternary ammonium salts of piperidinylethyl esters of alkoxysubstituted phenylcarbamic acids. | |
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MedLine Citation:
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PMID: 16821706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of 17 halogenides of quaternary ammonium salts of the alkylpiperidinylethyl esters of 2-pentoxy (and 2-heptoxy) substituted phenylcarbamic acids were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, M. kansasii, and M. avium. Correlation of this action with lipophilicity (log P, 1-octanol-water system) was used for the description of the structure-antimycobacterial activity relationships (QSARs). The activity increased with the increasing lipophilicity of the compounds. |
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Authors:
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K Waisser; R Dolezal; K Palát; J Cizmárik; J Kaustová |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Folia microbiologica Volume: 51 ISSN: 0015-5632 ISO Abbreviation: Folia Microbiol. (Praha) Publication Date: 2006 |
Date Detail:
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Created Date: 2006-07-06 Completed Date: 2006-10-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376757 Medline TA: Folia Microbiol (Praha) Country: Czech Republic |
Other Details:
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Languages: eng Pagination: 21-4 Citation Subset: IM |
Affiliation:
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Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czechia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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chemistry,
pharmacology* Antitubercular Agents / pharmacology* Microbial Sensitivity Tests Molecular Structure Mycobacterium avium / drug effects* Mycobacterium kansasii / drug effects* Mycobacterium tuberculosis / drug effects* Phenylcarbamates / chemistry, pharmacology* Quantitative Structure-Activity Relationship Quaternary Ammonium Compounds / chemistry, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Antitubercular Agents; 0/Phenylcarbamates; 0/Quaternary Ammonium Compounds |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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