Document Detail


QSAR study of antimycobacterial activity of quaternary ammonium salts of piperidinylethyl esters of alkoxysubstituted phenylcarbamic acids.
MedLine Citation:
PMID:  16821706     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of 17 halogenides of quaternary ammonium salts of the alkylpiperidinylethyl esters of 2-pentoxy (and 2-heptoxy) substituted phenylcarbamic acids were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis, M. kansasii, and M. avium. Correlation of this action with lipophilicity (log P, 1-octanol-water system) was used for the description of the structure-antimycobacterial activity relationships (QSARs). The activity increased with the increasing lipophilicity of the compounds.
Authors:
K Waisser; R Dolezal; K Palát; J Cizmárik; J Kaustová
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Folia microbiologica     Volume:  51     ISSN:  0015-5632     ISO Abbreviation:  Folia Microbiol. (Praha)     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-06     Completed Date:  2006-10-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376757     Medline TA:  Folia Microbiol (Praha)     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  IM    
Affiliation:
Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czechia.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / chemistry,  pharmacology*
Antitubercular Agents / pharmacology*
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium avium / drug effects*
Mycobacterium kansasii / drug effects*
Mycobacterium tuberculosis / drug effects*
Phenylcarbamates / chemistry,  pharmacology*
Quantitative Structure-Activity Relationship
Quaternary Ammonium Compounds / chemistry,  pharmacology*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antitubercular Agents; 0/Phenylcarbamates; 0/Quaternary Ammonium Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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