Document Detail

QRS slopes for detection and characterization of myocardial ischemia.
MedLine Citation:
PMID:  18269981     Owner:  NLM     Status:  MEDLINE    
In this study, the upward I(US) and downward I(DS) slopes of the QRS complex are proposed as indices for quantifying ischemia-induced electrocardiogram (ECG) changes. Using ECG recordings acquired before and during percutaneous transluminal coronary angioplasty (PTCA), it is found that the QRS slopes are considerably less steep during artery occlusion, in particular for I(DS). With respect to ischemia detection, the slope indices outperform the often used high-frequency index (defined as the root mean square (rms) of the bandpass-filtered QRS signal for the frequency band 150-250 Hz) as the mean relative factors of change are much larger for I(US) and I(DS) than for the high-frequency index (6.9 and 7.3 versus 3.7). The superior performance of the slope indices is equally valid when other frequency bands of the high-frequency index are investigated (the optimum one is found to be 125-175 Hz). Employing a simulation model in which the slopes of a template QRS are altered by different techniques, it is found that the slope changes observed during PTCA are mostly due to a widening of the QRS complex or a decrease of its amplitudes, but not a reduction of its high-frequency content or a combination of this and the previous effects. It is concluded that QRS slope information can be used as an adjunct to the conventional ST segment analysis in the monitoring of myocardial ischemia.
Esther Pueyo; Leif Sornmo; Pablo Laguna
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  IEEE transactions on bio-medical engineering     Volume:  55     ISSN:  1558-2531     ISO Abbreviation:  IEEE Trans Biomed Eng     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-13     Completed Date:  2008-03-14     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0012737     Medline TA:  IEEE Trans Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  468-77     Citation Subset:  IM    
Communications Technology Group at the Aragón Institute for Engineering Research (I3A), University of Zaragoza, Zaragoza 50015, Spain.
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MeSH Terms
Angioplasty, Balloon*
Diagnosis, Computer-Assisted / methods*
Electrocardiography / methods*
Myocardial Ischemia / diagnosis*,  surgery*
Reproducibility of Results
Sensitivity and Specificity
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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