Document Detail

Pyruvate-fortified fluid resuscitation improves hemodynamic stability while suppressing systemic inflammation and myocardial oxidative stress after hemorrhagic shock.
MedLine Citation:
PMID:  20358705     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine whether controlled resuscitation with pyruvate-fortified Ringer's (PR) solution vs. conventional lactate Ringer's (LR) more effectively stabilizes mean arterial pressure (MAP) and suppresses myocardial inflammation postresuscitation. METHODS: Goats were hemorrhaged (255 +/- 22 ml) to lower MAP to 48 +/- 1 mmHg. Next, the right femoral vessels were occluded for 90 min to model tourniquet application. Beginning at 30 min occlusion, LR or PR was infused i.v. at 10 ml/min for 90 min. The femoral occlusions were released at 60 min infusion. RESULTS: At 4 h postocclusion, MAP (mmHg) was increased in PR (59 +/- 4) vs. LR (47 +/- 3) resuscitated goats (p < 0.05). PR also more effectively augmented circulating HCO3 and total base excess. Nitrosative stress, detected in myocardium 4 h after LR resuscitation, was suppressed by PR. Finally, PR prevented the increase in circulating neutrophils that accompanied LR resuscitation. CONCLUSIONS: Relative to LR, resuscitation with PR more effectively stabilized MAP, suppressed myocardial nitrosative stress and minimized systemic inflammation after hemorrhagic shock with hindlimb ischemia-reperfusion.
Devin C Flaherty; Besim Hoxha; Jie Sun; Hunaid Gurji; Jerry W Simecka; Robert T Mallet; Albert H Olivencia-Yurvati
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Military medicine     Volume:  175     ISSN:  0026-4075     ISO Abbreviation:  Mil Med     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-02     Completed Date:  2010-06-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984771R     Medline TA:  Mil Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  166-72     Citation Subset:  IM    
Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, USA.
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MeSH Terms
Disease Models, Animal
Drug Combinations
Fluid Therapy / methods*
Hemodynamics / drug effects,  physiology*
Inflammation / etiology,  therapy*
Infusions, Intravenous
Isotonic Solutions / administration & dosage,  pharmacokinetics
Lactates / metabolism
Leukocyte Count
Myocardium / metabolism*
Oxidative Stress*
Pyruvic Acid / administration & dosage*,  pharmacokinetics
Resuscitation / methods
Shock, Hemorrhagic / complications*,  metabolism,  therapy
Treatment Outcome
Tyrosine / analogs & derivatives,  metabolism
Reg. No./Substance:
0/Drug Combinations; 0/Isotonic Solutions; 0/Lactates; 127-17-3/Pyruvic Acid; 3604-79-3/3-nitrotyrosine; 55520-40-6/Tyrosine; 8022-63-7/Ringer's lactate

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