| Pyruvate-fortified fluid resuscitation improves hemodynamic stability while suppressing systemic inflammation and myocardial oxidative stress after hemorrhagic shock. | |
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MedLine Citation:
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PMID: 20358705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine whether controlled resuscitation with pyruvate-fortified Ringer's (PR) solution vs. conventional lactate Ringer's (LR) more effectively stabilizes mean arterial pressure (MAP) and suppresses myocardial inflammation postresuscitation. METHODS: Goats were hemorrhaged (255 +/- 22 ml) to lower MAP to 48 +/- 1 mmHg. Next, the right femoral vessels were occluded for 90 min to model tourniquet application. Beginning at 30 min occlusion, LR or PR was infused i.v. at 10 ml/min for 90 min. The femoral occlusions were released at 60 min infusion. RESULTS: At 4 h postocclusion, MAP (mmHg) was increased in PR (59 +/- 4) vs. LR (47 +/- 3) resuscitated goats (p < 0.05). PR also more effectively augmented circulating HCO3 and total base excess. Nitrosative stress, detected in myocardium 4 h after LR resuscitation, was suppressed by PR. Finally, PR prevented the increase in circulating neutrophils that accompanied LR resuscitation. CONCLUSIONS: Relative to LR, resuscitation with PR more effectively stabilized MAP, suppressed myocardial nitrosative stress and minimized systemic inflammation after hemorrhagic shock with hindlimb ischemia-reperfusion. |
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Authors:
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Devin C Flaherty; Besim Hoxha; Jie Sun; Hunaid Gurji; Jerry W Simecka; Robert T Mallet; Albert H Olivencia-Yurvati |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Military medicine Volume: 175 ISSN: 0026-4075 ISO Abbreviation: Mil Med Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-02 Completed Date: 2010-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984771R Medline TA: Mil Med Country: United States |
Other Details:
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Languages: eng Pagination: 166-72 Citation Subset: IM |
Affiliation:
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Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Drug Combinations Fluid Therapy / methods* Goats Hemodynamics / drug effects, physiology* Inflammation / etiology, therapy* Infusions, Intravenous Isotonic Solutions / administration & dosage, pharmacokinetics Lactates / metabolism Leukocyte Count Male Myocardium / metabolism* Neutrophils Oxidative Stress* Pyruvic Acid / administration & dosage*, pharmacokinetics Resuscitation / methods Shock, Hemorrhagic / complications*, metabolism, therapy Treatment Outcome Tyrosine / analogs & derivatives, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Isotonic Solutions; 0/Lactates; 127-17-3/Pyruvic Acid; 3604-79-3/3-nitrotyrosine; 55520-40-6/Tyrosine; 8022-63-7/Ringer's lactate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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