Document Detail

Pyruvate dehydrogenase deficiency in a Sussex spaniel.
MedLine Citation:
PMID:  15049576     Owner:  NLM     Status:  MEDLINE    
A two-year-old, intact female Sussex spaniel was presented with signs of exercise intolerance. Pre- and post-exercise serum lactate and pyruvate concentrations and urinary organic acid screening supported a diagnosis of pyruvate dehydrogenase deficiency, as previously reported in this breed. Dietary therapy was initiated for six months, during which time there was no reported clinical deterioration. A full neurological examination and repeat evaluation of lactate and pyruvate concentrations before and after exercise was conducted one year after diagnosis, at which time the patient had been without dietary modification for six months and had developed more severe exercise intolerance along with evidence of central nervous system dysfunction.
C J Abramson; S R Platt; G D Shelton
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of small animal practice     Volume:  45     ISSN:  0022-4510     ISO Abbreviation:  J Small Anim Pract     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-30     Completed Date:  2004-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0165053     Medline TA:  J Small Anim Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  162-5     Citation Subset:  IM    
Centre for Small Animal Studies, Animal Health Trust, Suffolk CB8 7UU.
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MeSH Terms
Diagnosis, Differential
Dog Diseases / blood,  diagnosis*,  diet therapy
Lactic Acid / blood
Physical Conditioning, Animal
Pyruvate Dehydrogenase Complex Deficiency Disease / diagnosis,  veterinary*
Pyruvic Acid / blood
Reg. No./Substance:
127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid

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