| Pyruvate dehydrogenase deficiency in a Sussex spaniel. | |
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MedLine Citation:
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PMID: 15049576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A two-year-old, intact female Sussex spaniel was presented with signs of exercise intolerance. Pre- and post-exercise serum lactate and pyruvate concentrations and urinary organic acid screening supported a diagnosis of pyruvate dehydrogenase deficiency, as previously reported in this breed. Dietary therapy was initiated for six months, during which time there was no reported clinical deterioration. A full neurological examination and repeat evaluation of lactate and pyruvate concentrations before and after exercise was conducted one year after diagnosis, at which time the patient had been without dietary modification for six months and had developed more severe exercise intolerance along with evidence of central nervous system dysfunction. |
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Authors:
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C J Abramson; S R Platt; G D Shelton |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of small animal practice Volume: 45 ISSN: 0022-4510 ISO Abbreviation: J Small Anim Pract Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-30 Completed Date: 2004-05-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0165053 Medline TA: J Small Anim Pract Country: England |
Other Details:
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Languages: eng Pagination: 162-5 Citation Subset: IM |
Affiliation:
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Centre for Small Animal Studies, Animal Health Trust, Suffolk CB8 7UU. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diagnosis, Differential Dog Diseases / blood, diagnosis*, diet therapy Dogs Female Lactic Acid / blood Pedigree Physical Conditioning, Animal Pyruvate Dehydrogenase Complex Deficiency Disease / diagnosis, veterinary* Pyruvic Acid / blood |
| Chemical | |
Reg. No./Substance:
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127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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