| Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors. | |
| | |
MedLine Citation:
|
PMID: 23350847 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
We describe the discovery of several pyrrolopyrazines as potent and selective Syk inhibitors, and the efforts that eventually led to the desired improvements in physicochemical properties and human whole blood potencies. Ultimately, our mouse model revealed unexpected toxicity that precluded us from further advancing this series. |
| | |
Authors:
|
Fernando Padilla; Niala Bhagirath; Shaoqing Chen; Eric Chiao; David M Goldstein; Johannes Cornelius Hermann; Jonathan Hsu; Joshua Jahmil Kennedy-Smith; Andreas Kuglstatter; Cheng Liao; Wenjian Liu; Lee E Lowrie Jr; Kin-Chun Luk; Stephen M Lynch; John Menke; Linghao Niu; Tim Owens; Counde O-Yang; Aruna Railkar; Ryan C Schoenfeld; Michelle Slade; Sandra Steiner; Yun-Chou Tan; Armando G Villaseñor; Ce Wang; Jutta Wanner; Wenwei Xie; Daigen Xu; Xiaohu Zhang; Mingyan Zhou; Matthew Charles Lucas |
Related Documents
:
|
19786077 - Chronic inflammation and estradiol interact through mapk activation to affect tmj nocic... 23242997 - Structurally unique interaction of rbd-like and ph domains is crucial for yeast pheromo... 16514107 - Reelin induces the detachment of postnatal subventricular zone cells and the expression... 9920737 - Extracellular signal-regulated kinase mediates renal regeneration in rats with myoglobi... 16785567 - Peptidoglycan-induced il-6 production in raw 264.7 macrophages is mediated by cyclooxyg... 8207217 - Signal transduction pathway in human polymorphonuclear leukocytes for chemotaxis induce... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-28 |
Journal Detail:
|
Title: Journal of medicinal chemistry Volume: - ISSN: 1520-4804 ISO Abbreviation: J. Med. Chem. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genome sequence reveals that Pseudomonas fluorescens F113 possesses a large and diverse array of sys...
Next Document: Proteomics and metabolomics in renal transplantation-quo vadis?