Document Detail

Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.
MedLine Citation:
PMID:  23350847     Owner:  NLM     Status:  Publisher    
We describe the discovery of several pyrrolopyrazines as potent and selective Syk inhibitors, and the efforts that eventually led to the desired improvements in physicochemical properties and human whole blood potencies. Ultimately, our mouse model revealed unexpected toxicity that precluded us from further advancing this series.
Fernando Padilla; Niala Bhagirath; Shaoqing Chen; Eric Chiao; David M Goldstein; Johannes Cornelius Hermann; Jonathan Hsu; Joshua Jahmil Kennedy-Smith; Andreas Kuglstatter; Cheng Liao; Wenjian Liu; Lee E Lowrie Jr; Kin-Chun Luk; Stephen M Lynch; John Menke; Linghao Niu; Tim Owens; Counde O-Yang; Aruna Railkar; Ryan C Schoenfeld; Michelle Slade; Sandra Steiner; Yun-Chou Tan; Armando G Villaseñor; Ce Wang; Jutta Wanner; Wenwei Xie; Daigen Xu; Xiaohu Zhang; Mingyan Zhou; Matthew Charles Lucas
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  -     ISSN:  1520-4804     ISO Abbreviation:  J. Med. Chem.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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