Document Detail

Pyrrolizidine alkaloidosis of cattle associated with Senecio lautus.
MedLine Citation:
PMID:  7945096     Owner:  NLM     Status:  MEDLINE    
Serious incidents of pyrrolizidine alkaloidosis of cattle in 10 herds exposed to the Australian native plant, Senecio lautus (Asteraceae), were seen in central Queensland during 1988-1992. The deaths of 226 cattle were recorded. A mean of 8% of cattle died in affected groups (range 2 to 58%). Sickness and deaths usually occurred some months after access to S lautus. Typically, affected cattle lost body condition to the point of emaciation before dying and had persistent diarrhoea. Some animals developed abnormal behaviour and died after a shorter illness. Liver specimens from affected cattle in all herds contained lesions consistent with pyrrolizidine alkaloidosis. Thin layer chromatography of extracts of blood and liver samples from cattle from 5 herds detected pyrrolic metabolites. The identity of these was confirmed by mass spectroscopy on samples from one herd. Unseasonal autumn and winter rain after a dry summer appeared to favour growth of S lautus at the expense of other pasture species. A subsequent dry period promoted consumption of S lautus and was followed by a cluster of poisoning incidents.
J W Noble; J Crossley; B D Hill; R J Pierce; R A McKenzie; M Debritz; A A Morley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Australian veterinary journal     Volume:  71     ISSN:  0005-0423     ISO Abbreviation:  Aust. Vet. J.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-11-18     Completed Date:  1994-11-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370616     Medline TA:  Aust Vet J     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  196-200     Citation Subset:  IM    
Queensland Department of Primary Industries, Emerald.
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MeSH Terms
Cattle Diseases / epidemiology,  etiology*,  pathology
Liver / pathology
Plant Poisoning / epidemiology,  etiology,  pathology,  veterinary*
Plants, Toxic*
Pyrrolizidine Alkaloids / poisoning*
Queensland / epidemiology
Reg. No./Substance:
0/Pyrrolizidine Alkaloids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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