| Pyritinol reduces nociception and oxidative stress in diabetic rats. | |
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MedLine Citation:
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PMID: 18593582 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to assess the antinociceptive and antiallodynic effect of pyritinol as well as its possible mechanism of action in diabetic rats. Streptozotocin (50 mg/kg) injection caused hyperglycemia within 1 week. Formalin-evoked flinching was increased in diabetic rats as compared to non-diabetic rats. Oral acute administration of pyritinol (50-200 mg/kg) dose-dependently reduced flinching behavior in diabetic rats. Moreover, prolonged administration of pyritinol (12.5-50 mg/kg, every 2 days for 2 weeks) reduced formalin-induced nociception. 1H-[1,2,4]-oxadiazolo [4,3-a] quinoxalin-1-one (ODQ, a guanylyl cyclase inhibitor, 2 mg/kg, i.p.), but not naltrexone (a non-selective opioid receptor antagonist, 1 mg/kg, s.c.) or indomethacin (a non-selective cycloxygenase inhibitor, 5 mg/kg, i.p.), blocked the pyritinol-induced antinociception in diabetic rats. Given alone ODQ, naltrexone or indomethacin did not modify formalin-induced nociception in diabetic rats. Oral acute (200 mg/kg) or prolonged (25 mg/kg, every 2 days for 2 weeks) administration of pyritinol significantly reduced streptozotocin-induced changes in free carbonyls, dityrosine, malondialdehyde and advanced oxidative protein products. Four to 8 weeks after diabetes induction, tactile allodynia was observed in the streptozotocin-injected rats. On this condition, oral administration of pyritinol (50-200 mg/kg) reduced tactile allodynia in diabetic rats. Results indicate that pyritinol is able to reduce formalin-induced nociception and tactile allodynia in streptozotocin-injected rats. In addition, data suggest that activation of guanylyl cyclase and the scavenger properties of pyritinol, but not improvement in glucose levels, play an important role in these effects. |
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Authors:
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Guillermina Yanek Jiménez-Andrade; Gerardo Reyes-García; Gabriela Sereno; Guillermo Ceballos-Reyes; Guadalupe C Vidal-Cantú; Vinicio Granados-Soto |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-18 |
Journal Detail:
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Title: European journal of pharmacology Volume: 590 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-04 Completed Date: 2008-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 170-6 Citation Subset: IM |
Affiliation:
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Escuela de Biología, Benemérita Universidad Autónoma de Puebla, Puebla, Puebla, Mexico. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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pharmacology* Animals Diabetes Mellitus, Experimental / physiopathology* Female Indomethacin / pharmacology Naltrexone / pharmacology Oxadiazoles / pharmacology Oxidative Stress / drug effects* Pyrithioxin / pharmacology* Quinoxalines / pharmacology Rats Rats, Wistar Streptozocin |
| Chemical | |
Reg. No./Substance:
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0/1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one; 0/Analgesics; 0/Oxadiazoles; 0/Quinoxalines; 1098-97-1/Pyrithioxin; 16590-41-3/Naltrexone; 18883-66-4/Streptozocin; 53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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