| Pyrimidine nucleoside phosphorylase and dihydropyrimidine dihydrogenase activities as predictive factors for the efficacy of doxifluridine together with mitomycin C as adjuvant chemotherapy in primary colorectal cancer. | |
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MedLine Citation:
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PMID: 17629045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Pyrimidine Nucleoside Phosphorylase (PyNPase) converts 5'-deoxy-5-fluorouridine (5'-DFUR, doxifluridine) to 5-fluorouracil (5-FU). While this reaction is taking place Dihydropyrimidine Dihydrogenase (DPD) catalyzes 5-FU to inactive molecules. Mitomycin C (MMC) elevates the PyNPase level in tumor cells. METHODOLOGY: We investigated 17 colorectal cancer patients' PyNPase and DPD activities in tumor and normal tissues using an enzyme-linked immunosorbent assay (ELISA) to assess their clinical significance as indicators for selecting colorectal cancer patients for 5'-DFUR together with MMC as adjuvant chemotherapy. RESULTS: Six of 17 patients developed experienced a recurrence. Tumor DPD activity of the 6 patients who had a recurrence were higher than those of the 11 patients with no recurrence (p = 0.047). On the other hand, there were no significant differences in both the PyNPase and the PyNPase/DPD (P/D) ratio between the group with recurrence and the group without recurrence. For survival analyses, we designed the cut-off value of tumor PyNPase, DPD and P/D ratio as their median value and classified patients into a higher group and a lower group, but there were no significant differences between the groups. CONCLUSIONS: The DPD activity in the tumor may be a useful indicator for selecting patients likely respond to 5'-DFUR together with MMC as adjuvant chemotherapy. If tumor DPD is high, we had better select a different anticancer drug. |
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Authors:
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Masanori Nishioka; Hidenori Miyamoto; Nobuhiro Kurita; Jun Higashijima; Kouzou Yoshikawa; Tomohiko Miyatani; Mitsuo Shimada |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 54 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-07-16 Completed Date: 2007-08-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
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Languages: eng Pagination: 1089-93 Citation Subset: IM |
Affiliation:
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Department of Digestive and Pediatric Surgery, Institute of Health Biosciences The University of Tokushima Graduate School, Tokushima, Japan. mnishioka@clin.med.tokushima-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antineoplastic Protocols Chemotherapy, Adjuvant Colorectal Neoplasms / drug therapy*, enzymology, mortality Dihydrouracil Dehydrogenase (NADP) / analysis* Female Floxuridine / therapeutic use* Humans Male Middle Aged Mitomycin / therapeutic use* Pentosyltransferases / analysis* Prognosis Recurrence Survival Analysis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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3094-09-5/doxifluridine; 50-07-7/Mitomycin; 50-91-9/Floxuridine; EC 1.3.1.2/Dihydrouracil Dehydrogenase (NADP); EC 2.4.2.-/Pentosyltransferases; EC 2.4.2.2/pyrimidine-nucleoside phosphorylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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