Document Detail


Pyridoxine-related metabolite concentrations in normal and Down syndrome amniotic fluid.
MedLine Citation:
PMID:  18417989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Some studies of children with Down syndrome have found mild abnormalities in the metabolism of pyridoxine (vitamin B(6)); therefore the present question is whether such abnormalities might also be present in the amniotic fluid of fetuses with Down syndrome.
MATERIALS AND METHODS: Archived specimens of amniotic fluid were obtained from chromosomally normal and from fetuses with Down syndrome. Gas chromatography/mass spectrometry quantitized B-related metabolites, including oxalate, xanthurenate, kynurenine and 4-pyridoxic acid.
RESULTS: Oxalate, a marker of pyridoxine deficiency, was elevated in the amniotic fluid of fetuses with Down syndrome. This result was statistically significant. The other marker results were not statistically significant.
CONCLUSION: A marker of pyridoxine deficiency, oxalate is elevated in the amniotic fluid of fetuses with Down syndrome. These results in amniotic fluid are consistent with previous studies done in the urine of young children.
Authors:
Paddy Jim Baggot; Anna Jane Y Eliseo; Nathaniel G DeNicola; Jeremy A Kalamarides; James D Shoemaker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-14
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  23     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-17     Completed Date:  2008-06-04     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  254-7     Citation Subset:  IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel.
Affiliation:
Hollywood Presbyterian Medical Center, Los Angeles, CA, USA. pjbaggot@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Amniotic Fluid / metabolism*
Biological Markers / metabolism
Case-Control Studies
Down Syndrome / diagnosis,  metabolism*
Female
Humans
Kynurenine / metabolism
Oxalic Acid / metabolism
Pregnancy
Prenatal Diagnosis
Pyridoxic Acid / metabolism
Pyridoxine / metabolism*
Retrospective Studies
Xanthurenates / metabolism
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Xanthurenates; 144-62-7/Oxalic Acid; 343-65-7/Kynurenine; 58LAB1BG8J/xanthurenic acid; 65-23-6/Pyridoxine; 82-82-6/Pyridoxic Acid
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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