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Pyridoxamine protects against mechanical defects in cardiac aging in rats: Studies on load dependence of myocardial relaxation.
MedLine Citation:
PMID:  25239923     Owner:  NLM     Status:  Publisher    
Our team demonstrated in the past that pyridoxamine attenuated arterial stiffening by targeting the pathogenic formation of glycated collagen cross-links in aged rats. Herein, we examined whether pyridoxamine therapy can protect against mechanical defects in myocardial relaxation by improving arterial wave properties and cardiac contractile performance in senescence animals. Fifteen-month-old male Fisher 344 rats were treated daily with pyridoxamine (1 g L(-1) in drinking water) for 5 months and compared with age-matched untreated controls (20 mo). Arterial wave properties were characterized by wave transit time (τw) and wave reflection factor (Rf). We measured the contractile status of the myocardium in an intact heart as the left ventricular (LV) end-systolic elastance (Ees). Myocardial relaxation was described according to the time constant of the LV isovolumic pressure decay (τe). Pyridoxamine therapy prevented the age-associated prolongation in LV τe and the diminished Ees in senescent rats. The drug also attenuated the age-related augmentation in afterload imposed on the heart, as evidenced by the increased τw and decreased Rf. We found that the LV τe was significantly influenced by both the arterial τw and Rf (τe = 16.3902+8.3123×Rf-0.4739×τw; r = 0.7048, P<0.005). In the meantime, the LV τe and the LV Ees showed a significant inverse linear correlation (τe=13.9807-0.0068×Ees; r=0.6451, P<0.0005). All these findings suggested that long term treatment with pyridoxamine might ameliorate myocardial relaxation rate, partially at least through its ability to enhance myocardial contractile performance, increase wave transit time, and decrease wave reflection factor in aged rats. This article is protected by copyright. All rights reserved.
Chih-Hsien Wang; En-Ting Wu; Ming-Shiou Wu; Ming-Shian Tsai; Ya-Hui Ko; Ru-Wen Chang; Chun-Yi Chang; Kuo-Chu Chang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-18
Journal Detail:
Title:  Experimental physiology     Volume:  -     ISSN:  1469-445X     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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