Document Detail

Pyridostigmine prevents haemodynamic alterations but does not affect their nycthemeral oscillations in infarcted mice.
MedLine Citation:
PMID:  25434306     Owner:  NLM     Status:  Publisher    
The increase in acetylcholine yielded by pyridostigmine (PYR), an acetylcholinesterase inhibitor, was evaluated for its effect on the haemodynamic responses-mean arterial pressure (MAP) and heart rate (HR)-and their nycthemeral oscillation in mice before and one week after myocardial infarction (MI). Mice were anesthetized (isoflurane), and a telemetry transmitter was implanted into the carotid artery. After 5days of recovery, the MAP and HR were recorded for 48h (10s every 10min). Following this procedure, mice were submitted to surgery for sham or coronary artery ligation and received drinking water (VEHICLE) with or without PYR. Five days after surgery, the haemodynamic recordings were recommenced. Sham surgery combined with VEHICLE did not affect basal MAP and HR; nevertheless, these haemodynamic parameters were higher during the night, before and after surgery. MI combined with VEHICLE displayed decreased MAP and increased HR; these haemodynamic parameters were also higher during the night, before and after surgery. Sham surgery combined with PYR displayed similar results for MAP as sham combined with VEHICLE; however, PYR produced bradycardia. Nevertheless, MI combined with PYR exhibited no change in MAP and HR, but these haemodynamic parameters were also higher during the night, before and after surgery. Therefore, MI decreased MAP and increased HR, while PYR prevented these alterations. Neither MI nor PYR affected nycthemeral oscillations of MAP and HR. These findings indicate that the increase in acetylcholine yielded by PYR protected the haemodynamic alterations caused by MI in mice, without affecting the nycthemeral haemodynamic oscillations.
Wesley G Corrêa; Marina T Durand; Christiane Becari; Geisa C S V Tezini; Jussara M do Carmo; Mauro de Oliveira; Cibele M Prado; Rubens Fazan; Helio C Salgado
Related Documents :
21425056 - Heart failure resulting from giant left atrial synovial sarcoma metastasis.
25180276 - Rapid regression of left ventricular outflow tract rhabdomyoma after sirolimus therapy.
17942236 - Morphology and topography of nucleus ambiguus projections to cardiac ganglia in rats an...
22212436 - The missing left atrial appendage.
12766746 - Clinical and angiographic efficacy of a self-expanding nitinol stent in saphenous vein ...
19163016 - Comparison of the electrophysiologically based optimization methods with different paci...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-21
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  -     ISSN:  1872-7484     ISO Abbreviation:  Auton Neurosci     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-1     Completed Date:  -     Revised Date:  2014-12-2    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier B.V. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Highly dispersed Fe2O3 on carbon nanotubes for low-temperature selective catalytic reduction of NO w...
Next Document:  Synergistic antitumor effect of puerarin combined with 5-fluorouracil on gastric carcinoma.