Document Detail

Pyridostigmine bromide does not alter thermoregulation during exercise in cold air.
MedLine Citation:
PMID:  7828087     Owner:  NLM     Status:  MEDLINE    
This study examined the effects of acute and chronic pyridostigmine bromide (PB) administration on thermoregulatory and metabolic responses to exercise in cold air (5 degrees C). Seven healthy men completed two 7-day trials in a double-blind, crossover experimental design: during one trial they received PB (30 mg three times daily) and during the other trial they received placebo. For each trial, subjects attempted four (3 h) exercise tests: low-intensity exercise (approximately 25% VO2max) and moderate-intensity exercise (approximately 50% VO2max), on days 2 and 3 and again on days 6 and 7. Metabolic rate, body temperatures, and venous blood samples were obtained before and during exercise. Red blood cell acetylcholinesterase inhibition induced by PB increased (p < 0.05) from 34% on day 1 to 43% on days 3-7. Metabolic rate, body temperatures, and regional heat conductance responses were not different between trials. Plasma glucose, glycerol, free fatty acid, lactate, sodium, and potassium concentrations were not different between trials. In addition, differences were not found between acute and chronic experiments for any thermoregulatory or metabolic responses. These findings demonstrate that the PB dosage used by military personnel, as a pharmacological defense against nerve-agent poisoning, should not cause any adverse thermoregulatory or metabolic effects during moderate activity in cold climates.
D E Roberts; M N Sawka; A J Young; B J Freund
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  72     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1995-02-23     Completed Date:  1995-02-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  788-93     Citation Subset:  IM; S    
U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760-5007.
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MeSH Terms
Body Temperature Regulation / drug effects*
Cholinesterases / blood
Cold Temperature*
Cross-Over Studies
Double-Blind Method
Erythrocytes / drug effects,  enzymology
Exercise / physiology*
Heart Rate / drug effects
Muscle, Skeletal / blood supply,  drug effects
Oxygen Consumption / drug effects
Pyridostigmine Bromide / pharmacology*
Regional Blood Flow / drug effects
Reg. No./Substance:
101-26-8/Pyridostigmine Bromide; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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