| Pyridostigmine bromide does not alter thermoregulation during exercise in cold air. | |
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MedLine Citation:
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PMID: 7828087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study examined the effects of acute and chronic pyridostigmine bromide (PB) administration on thermoregulatory and metabolic responses to exercise in cold air (5 degrees C). Seven healthy men completed two 7-day trials in a double-blind, crossover experimental design: during one trial they received PB (30 mg three times daily) and during the other trial they received placebo. For each trial, subjects attempted four (3 h) exercise tests: low-intensity exercise (approximately 25% VO2max) and moderate-intensity exercise (approximately 50% VO2max), on days 2 and 3 and again on days 6 and 7. Metabolic rate, body temperatures, and venous blood samples were obtained before and during exercise. Red blood cell acetylcholinesterase inhibition induced by PB increased (p < 0.05) from 34% on day 1 to 43% on days 3-7. Metabolic rate, body temperatures, and regional heat conductance responses were not different between trials. Plasma glucose, glycerol, free fatty acid, lactate, sodium, and potassium concentrations were not different between trials. In addition, differences were not found between acute and chronic experiments for any thermoregulatory or metabolic responses. These findings demonstrate that the PB dosage used by military personnel, as a pharmacological defense against nerve-agent poisoning, should not cause any adverse thermoregulatory or metabolic effects during moderate activity in cold climates. |
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Authors:
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D E Roberts; M N Sawka; A J Young; B J Freund |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Canadian journal of physiology and pharmacology Volume: 72 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1995-02-23 Completed Date: 1995-02-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: CANADA |
Other Details:
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Languages: eng Pagination: 788-93 Citation Subset: IM; S |
Affiliation:
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U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760-5007. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Temperature Regulation / drug effects* Cholinesterases / blood Cold Temperature* Cross-Over Studies Double-Blind Method Erythrocytes / drug effects, enzymology Exercise / physiology* Heart Rate / drug effects Humans Male Muscle, Skeletal / blood supply, drug effects Oxygen Consumption / drug effects Pyridostigmine Bromide / pharmacology* Regional Blood Flow / drug effects |
| Chemical | |
Reg. No./Substance:
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101-26-8/Pyridostigmine Bromide; EC 3.1.1.8/Cholinesterases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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